2yb8: Difference between revisions

<table><tr><td colspan='2'>[[2yb8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YB8 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xyi|2xyi]], [[2yba|2yba]]</div></td></tr>

[[https://www.uniprot.org/uniprot/SUZ12_DROME SUZ12_DROME]] Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. [[https://www.uniprot.org/uniprot/CAF1_DROME CAF1_DROME]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.<ref>PMID:8887645</ref> <ref>PMID:9419341</ref> <ref>PMID:9784495</ref> <ref>PMID:12490953</ref> <ref>PMID:15456884</ref> 

*[[Polycomb|Polycomb]]

[[Category: Drome]]

[[Category: Aiwazian, J]]

[[Category: Bauer, A]]

[[Category: Bouwmeester, T]]

[[Category: Bunker, R D]]

[[Category: Chan, H]]

[[Category: Faty, M]]

[[Category: Fischle, W]]

[[Category: Gu, J]]

[[Category: Gut, H]]

[[Category: Hess, D]]

[[Category: Li, L]]

[[Category: Lingaraju, G M]]

[[Category: Ly-Hartig, N]]

[[Category: Muller, J]]

[[Category: Prusty, A B]]

[[Category: Sack, R]]

[[Category: Schmitges, F W]]

[[Category: Stutzer, A]]

[[Category: Thoma, N H]]

[[Category: Wirth, U]]

[[Category: Zhao, K]]

[[Category: Zhou, S]]

[[Category: Wd40 domain]]