Nitric Oxide Synthase 3D structures

3D Structures of Nitric Oxide Synthase

Updated on 23-March-2026

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• Endothelial NOS oxygenase domain (OD) 66-492
  • 3nos, 4d1o – h-eNOS OD+ Arg - human
  • 1m9j – h-eNOS OD+chlorzoxazone
  • 1m9k, 1m9r, 3eah, 4d1p, 6av6, 6av7, 6cie, 6cif, 6nh1, 6nh2, 6nh3, 6nh4, 6nh5, 6nh6, 6nh7, 6nh8, 6nhf – h-eNOS OD+ inhibitor
  • 1nsi - h-eNOS OD+ Zn
  • 3dqs, 3dqt, 3jww, 3jwx, 3jwy, 3jwz, 3nld, 3nle, 3nlf, 3nlg, 3pnh, 4luw – b-eNOS OD+ pyridine derivative – bovine
  • 1dm6 – b-eNOS OD+guanidine derivative
  • 3nlh, 3rqo, 3rqp – b-eNOS OD (mutant)+ pyridine derivative
  • 1p6n, 1rs8, 1rs9 – b-eNOS OD +dipeptide inhibitor
  • 1nse – b-eNOS OD
  • 1dm7, 1fol, 1foo, 1fop, 2nse, 3nse, 4nse, 5nse, – b-eNOS OD+ Arg derivative
  • 7nse – b-eNOS OD+ADMA
  • 1d1v, 1d1x, 1d1y, 1ed4, 9nse – b-eNOS OD+urea derivative
  • 1dmj, 1dmk – b-eNOS OD+pterin derivative
  • 1dmi, 1foi, 1i83, 3e7s, 3n5p, 3n5q, 3n5r, 3n5s, 3n5t, 3n5v, 3n5w, 3n5x, 3n5y, 3n5z, 3n60, 3n61, 3n62, 3n63, 3n64, 3n65, 3n66, 3n67, 3n68, 3n69, 3n6a, 3n6b, 3n6c, 3n6d, 3n6e, 3n6f, 3n6g, 3nlt, 3nlu, 4cty, 4ctz, 4cu0, 4cu1, 4cul, 4cum, 4cun, 4cvg, 4cwv, 4cww, 4cwx, 4cwy, 4d33, 4d34, 4d35, 4d36, 4d37, 4d38, 4d39, 4d3a, 4upq, 4upr, 4ups, 4upt, 5adj, 5adk, 5adl, 5adm, 5adn, 5fj2, 5fj3, 5fvy, 5fvz, 5vv6, 5vv7, 5vv8, 5vv9, 5vva, 5vvb, 5vvc, 5vvd, 5vvg, 5vvn, 5uo8, 5uo9, 5uoa, 5uob, 5uoc, 5uod – b-eNOS OD+inhibitor
  • 4cwz, 4cx0, 4cx1, 4cx2 – b-eNOS OD (mutant) +inhibitor
    
  • 1d0c, 1d0o, 1d1w, 1ed5, 1foj, 8nse – b-eNOS OD+indazole derivative
  • 1dm8 – b-eNOS OD+triazole derivative
  • 1ed6 – b-eNOS OD+NO
• Endothelial NOS heme domain
  • 6pou, 6pov, 6pow, 6pox, 6poy, 6poz, 6pp0, 6pp1, 6pp2, 6pp3, 6pp4, 7m56, 7tsg, 7tsh, 7tsi, 7tsk, 7tsl, 7tsm, 7tsn, 7tso, 7tsp, 7uao, 8fge, 8fgn, 8fgo, 8fgp, 8fgq, 8fgr, 8fgs, 8fgt, 8fgu, 8ufr, 8uft, 8ufu, 9c1z, 9cw5, 9cw6, 9cw7, 9cw9, 9cwj, 9cwk, 9mwo, 9mws, 9mwt, 9mwu, 9mwv, 9mww, 9mz1, 9mz2, 9mz3, 9mz4, 9q4y, 9q51, 9q52, 9q54, 9q55, 9q58 – h-eNOS heme domain + inhibitor
    
  • 6ng1, 6ng2, 6ng4, 6ng5, 6ng6, 6ng7, 6ng8, 6nga, 6ngb, 6ngc, 6ngd, 6nge, 6ngf, 6ngh, 6ngi – h-eNOS heme domain (mutant) + inhibitor
    
  • 1q2o – b-eNOS OD (mutant)+dipeptide inhibitor
  • 6nse - b-eNOS heme domain + canavanine
    
  • 1p6l, 1p6m – r-eNOS OD +dipeptide inhibitor – rat
  • 4c3a, 4imx, 4jsk, 4jsl, 4jsm, 4k5h, 4k5i, 4k5j, 4k5k – r-eNOS OD+ pyridine derivative
    
  • 4kcp, 4kcq, 4kcr, 4kcs - r-eNOS OD +thiophene carboximidamide derivative
    
  • 4uh0, 4uh1, 4uh2, 4uh3, 4uh4, 4uh7, 4uh8, 4uh9, 4uha, 6ngj, 6ngk, 6ngl, 6ngm, 6ngn, 6ngp, 6ngq, 6ngr, 6ngs, 6ngt, 6ngu, 6ngv, 6ngw, 6ngx, 6ngy, 6ngz, 6nh0 – r-eNOS heme domain + inhibitor
    
• Neuronal NOS; heme domain 297-718
  • 4uh5, 6av3, 6av4, 6av5, 7ts8, 7tsf, 9cvn, 9q4z - h-nNOS heme domain +inhibitor
    
  • 4uch, 4uh6, 5vuv, 5vuw, 5vux, 5vuy, 5vuz, 5vv1, 5vv2, 5vv4, 6auz, 6auy, 6av0, 6av1, 6av2, 6cic, 6cid, 6ng1, 6ng2, 6ng4, 6ng5, 6ng6, 6ng7, 6ng8, 6nga, 6ngb, 6ngc, 6ngd, 6nge, 6ngf, 6ngh, 6ngi, 6nhb, 6nhc, 6pna, 6pnb, 6pnc, 6pnd, 6pne, 6pnf, 6png, 6pnh, 6po5, 6po7, 6po8, 6po9, 6poa, 6pob, 6poc, 6pot, 7ts1, 7ts2, 7ts3, 7ts4, 7ts5, 7ts6, 7ts6, 7uam, 7us7, 7us8, 8fgf, 8fgg, 8fgh, 8fgi, 8fgk, 8fgl, 8fgm, 9cvo, 9cvp, 9cvq, 9cvs, 9cvu, 9cvv, 9cvx, 9cvy, 9cvz, 9cw0, 9cw1, 9cw3, 9myw, 9mwb, 9q4i, 9q4j, 9q4n, 9q4o, 9q4w - h-nNOS heme domain (mutant) +inhibitor
    
  • 4d1n - h-nNOS heme domain (mutant) + Arg
    
  • 4cam, 4can, 4cao, 4cap, 4caq, 4car, 4cdt, 4cft – r-nNOS heme domain + quinoline derivative
    
  • 4kch, 4kci, 4kcj, 4kck, 4kcl, 4kcm, 4kcn, 4kco - r-nNOS heme domain + carboximidamide derivative
    
  • 9mwa, 9mwc, 9mwe, 9mwf, 9mwg, 9mwh, 9mwk, 9mwm - r-nNOS heme domain (mutant) + carboximidamide derivative
    
  • 6nhd, 6nhe, 6pmv, 6pmw, 6pmx, 6pmy, 6pmz, 6pn0, 6pn1, 6pn2, 6pn3, 6pn4, 6pn5, 6pn6, 6pn7, 6pn8, 6pn9, 7s3x, 7s3y, 7s3z, 7s40, 8fgb, 8fgc - r-nNOS heme domain +inhibitor
    
  • 7ts9, 7tsa, 7tsb, 7tsc, 7tsd, 7tse, 7uan, 9cvi, 9cvl, 9myy, 9q4p, 9q4r, 9q4t - r-nNOS heme domain (mutant) + inhibitor
    
• Neuronal NOS; oxygenase domain (OD) 297-718
  • 2hx2 – b-nNOS OD+nitroguanidine derivative
  • 3nlv, 3nlw, 3nlx, 3nly, 3nlz, 3nm0 - b-nNOS OD + inhibitor
  • 3nlj, 3nlk, 3nln, 3nlo, 3nlp, 3nlq, 3nlr, 3jws, 3jwt, 3jwu, 3jwv, 3jx0, 3jx1, 3jx2, 3jx3, 3jx4, 3jx5, 3jx6, 3pne, 3pnf, 3png, 3svp, 3svq – r-nNOS OD (mutant)+pyridine derivative
  • 3b3m, 3b3n, 3b3o, 3b3p, 3n2r, 3nlm, 3nny, 3nnz, 3rqj, 3rqk, 3rql, 3rqm, 3rqn, 3tyl, 3tym, 3tyn, 3tyo, 4ims, 4imt, 4imu, 4imw, 4jse, 4jsf, 4jsg, 4jsh, 4jsi, 4jsj, 4k5d, 4k5e, 4k5f, 4k5g, 4lux – r-nNOS OD+ pyridine derivative
  • 1k2r, 1k2s, 1lzx, 1om4, 1qw6, 1zvl, 2hx4, 4fvw, 4fvx, 4fvy, 4fvz, 4fw0 – r-nNOS OD+ Arg derivative
  • 4gqe – r-nNOS OD + norvaline derivative
    
  • 1k2t, 1k2u – r-nNOS OD+thiourea derivative
  • 1om5 – r-nNOS OD+indazole derivative
  • 1lzz, 1m00, 2hx3 – r-nNOS OD+guanidine derivative
  • 1zvi, 3fc5 – r-nNOS OD
  • 1mmv, 1mmw, 1qwc, 3dqr, 3q99, 3q9a, 3ufo, 3ufp, 3ufq, 3ufr, 3ufs, 3uft, 3ufu, 3ufv, 3ufw, 4c39, 4ctp, 4ctq, 4ctr, 4ctt, 4ctu, 4ctv, 4ctw, 4ctx, 4d1z, 4d2y, 4d2z, 4d30, 4d31, 4d32, 4d33, 4d34, 4d35, 4d3b, 4d7o, 4eux, 4ugz, 4upm, 4upn, 4upo, 4upp, 4v3v, 4v3w, 4v3x, 4v3y, 4v3z, 5ad4, 5ad5, 5ad6, 5ad7, 5ad8, 5ad9, 5ada, 5adb, 5adc, 5vui, 5fvo, 5fvp, 5fvq, 5fvr, 5fvs, 5fvt, 5fw0, 5unr, 5unt, 5unu, 5unv, 5unw, 5unx, 5uny, 5unz, 5uo0, 5vuj, 5vuk, 5vul, 5vum, 5vun, 5vuo, 5vup, 5vuq, 5vur, 5vus, 5vut, 5vuu, 6auq, 6aur, 6aut, 6auu, 6auv, 6auw, 6aux, 6ngj, 6ngk, 6ngl, 6ngm, 6ngn, 6ngp, 6ngq, 6ngr, 6ngs, 6ngt, 6ngu, 6ngv, 6ngw, 6ngx, 6ngy, 6ngz, 6nh0, 6nhd, 6nhe, 7tsf – r-nNOS OD+inhibitor
  • 4cx3, 4cx4, 4cx5, 4cx6, 4v3u, 5add, 5ade, 5adf, 5adg, 5adi, 5fvu, 5fvv, 5fvx, 5fvw, 5g0n, 5g0o, 5g0p, 5uns, 5uo1, 5uo2, 5uo3, 5uo4, 5uo5, 5uo6, 5uo7, 5vv0, 5vv3, 5vv5, 6aus – r-nNOS OD (mutant) +inhibitor
    
  • 3jt3, 3jt4, 3jt5, 3jt6, 3jt7, 3jt8, 3jt9, 3jta – r-nNOS OD+ornithine derivative
  • 3hsn – r-nNOS OD+NHA+CO
  • 3hso, 3hsp - r-nNOS OD+NHA+NO
  • 2g6h, 2g6i, 2g6j – r-nNOS OD+pterin derivative
  • 2g6k, 2g6l – r-nNOS OD+pterin derivative+NO
  • 2g6m, 2g6n, 2g6o – r-nNOS OD+pterin derivative+CO
  • 1p6k, 1zzq, 1zzr, 1zzs, 1zzt, 1zzu – r-nNOS OD (mutant)+dipeptide inhibitor
  • 1p6h, 1p6i, 1p6j, 1rs6, 1rs7 – r-nNOS OD +dipeptide inhibitor
  • 1vag – m-nNOS OD+inhibitor – mouse
• Neuronal NOS; other domains
  • 8t1j - r-nNOS + Arg – Cryo EM
  • 1qau - r-nNOS PDZ domain
  • 1qav, 4hop - r-nNOS PDZ domain + α-1 syntrophin
  • 1b8q – r-nNOS PDZ domain + heptapeptide
  • 1f20 - r-nNOS FAD/NADP domain
  • 1tll – r-nNOS resdues 742-1429
    
• Inducible NOS
  • 3hr4 – h-iNOS residues 503-715+calmodulin
  • 3e7g, 3ej8, 4cx7, 4nos – h-iNOS OD+inhibitor
  • 4nsi – h-iNOS OD+ Arg
  • 2nsi – h-iNOS OD+thiourea derivative
  • 6key - h-iNOS OD + SOCS box protein
    
  • 1r35, 2nod, 3e65, 3eai, 3ebd, 3ebf, 3nsq – m-iNOS OD + pterin derivative
  • 1jwj, 1jwk – m-iNOS OD (mutant)+ pterin derivative
  • 4ux6 – m-iNOS OD + pterin derivative + inhibitor
    
  • 2bhj – m-iNOS OD+coumarin
  • 3nod – m-iNOS OD+product analog
  • 1noc – m-iNOS OD+chloramphenicol acetyltransferase
  • 3e67 – m-iNOS OD+4-MAP
  • 1dd7, 1qw5, 1vaf, 2y37, 3e68, 3e6l, 3e6n, 3e6o, 3e6t, 3e7i, 3e7m, 3e7t – m-iNOS OD+inhibitor
  • 1nos, 2oro, 2orp, 2orq, 2orr, 2ors, 2ort, 3nw2 – m-iNOS OD+imidazole derivative
  • 1df1 - m-iNOS OD+ urea derivative
  • 3dwj – m-iNOS OD (mutant)
  • 1qom, 4js9 - m-iNOS OD
  • 1dwv, 1dww, 1dwx, 1nod, 1qw4 – m-iNOS OD + Arg derivative
  • 2nos – m-iNOS OD+guanidine derivative
  • 1n2n – m-iNOS OD+CN
  • 1m9t – m-iNOS OD+indazole derivative
  • 1m8d – m-iNOS OD+chlorzoxazone
  • 1m8e, 1m8h, 1m8i, 1m9m, 1m9q – m-iNOS OD+ indazole derivative
  • 3gof - c-iNOS OD + calmodulin – chicken
    
• Prokaryote NOS
  • 2amo – BsNOS – Bacillus subtilis
  • 2an0, 2an2 – BsNOS (mutant)
  • 2fbz, 2fc1, 2fc2 – BsNOS+NO
  • 1m7v, 1m7z – BsNOS+THF+ Arg
  • 6xcx, 6xk3, 6xk4, 6xk5, 6xk6, 6xk7, 6xk8, 6xmc – BsNOS + inhibitor
    
  • 4d3v, 4d3u, 4d3t, 4d3o, 4d3n, 4d3m, 4d3k, 4d3j, 4d3i, 4d7h, 4d7i, 4d7j, 4lwa, 4lwb, 4ug5, 4ug6, 4ug7, 4ug8, 4ug9, 4uga, 4ugb, 4ugc, 4ugd, 4uge, 4ugf, 4ugg, 4ugh, 4ugi, 4ugj, 4ugk, 4ugl, 4ugm, 4ugn, 4ugo, 4ugp, 4ugq, 4ugr, 4ugs, 4ugt, 4ugu, 4ugv, 4ugw, 4ugx, 4ugy, 4uqr, 4uqs, 5g67, 5g6q, 5g6p, 5g6o, 5g6n, 5g6m, 5g6l, 5g6k, 5g6j, 5g6i, 5g6h, 5g6g, 5g6f, 5g6e, 5g6d, 5g6c, 5g6b, 5g6a, 5g69, 5g68, 5g66, 5g65 – BsNOS (mutant) + inhibitor
    
  • 2flq – NOS+ Arg – Geobacillus stearothermophilus
  • 9q0x – NOS – Synechococcus – Cryo EM

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