2bl9: Difference between revisions

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<StructureSection load='2bl9' size='340' side='right'caption='[[2bl9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2bl9' size='340' side='right'caption='[[2bl9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BL9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BL9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j3i|1j3i]], [[1j3j|1j3j]], [[1j3k|1j3k]], [[2bla|2bla]], [[2blb|2blb]], [[2blc|2blc]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bl9 OCA], [https://pdbe.org/2bl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bl9 RCSB], [https://www.ebi.ac.uk/pdbsum/2bl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bl9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bl9 OCA], [https://pdbe.org/2bl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bl9 RCSB], [https://www.ebi.ac.uk/pdbsum/2bl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bl9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DRTS_PLAVI DRTS_PLAVI] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dihydrofolate reductase]]
[[Category: Haemamoeba vivax]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chitnumsub, P]]
[[Category: Plasmodium vivax]]
[[Category: Khongsuk, P]]
[[Category: Chitnumsub P]]
[[Category: Kongsaeree, P]]
[[Category: Khongsuk P]]
[[Category: Leartsakulpanich, U]]
[[Category: Kongsaeree P]]
[[Category: Tarnchompoo, B]]
[[Category: Leartsakulpanich U]]
[[Category: Walkinshaw, M D]]
[[Category: Tarnchompoo B]]
[[Category: Yuthavong, Y]]
[[Category: Walkinshaw MD]]
[[Category: Drug resistance]]
[[Category: Yuthavong Y]]
[[Category: Malaria]]
[[Category: Oxidoreductase]]
[[Category: Plamodium vivax]]
[[Category: Pyrimethamine]]
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