7w3u: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 7w3u is ~~ON HOLD~~

==USP34 catalytic domain in complex with UbPA==

== Structural highlights ==

<table><tr><td colspan='2'>[[7w3u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W3U OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7W3U FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.13Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYE:PROP-2-EN-1-AMINE'>AYE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7w3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w3u OCA], [https://pdbe.org/7w3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w3u RCSB], [https://www.ebi.ac.uk/pdbsum/7w3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w3u ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/UBP34_HUMAN UBP34_HUMAN] Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.<ref>PMID:21383061</ref>

~~Authors: Xu, G.L., Ming, Z.H.~~

==See Also==

*[[Thioesterase 3D structures|Thioesterase 3D structures]]

~~Description~~: ~~USP34 catalytic domain in complex with UbPA~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: ~~Xu, G.L~~]]

__TOC__

[[Category: ~~Ming, Z.H~~]]

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Ming ZH]]

[[Category: Xu GL]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7w3u is ON HOLD
+==USP34 catalytic domain in complex with UbPA==
+<StructureSection load='7w3u' size='340' side='right'caption='[[7w3u]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7w3u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W3U FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYE:PROP-2-EN-1-AMINE'>AYE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w3u OCA], [https://pdbe.org/7w3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w3u RCSB], [https://www.ebi.ac.uk/pdbsum/7w3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w3u ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UBP34_HUMAN UBP34_HUMAN] Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.<ref>PMID:21383061</ref>
-Authors: Xu, G.L., Ming, Z.H.
+==See Also==
+*[[Thioesterase 3D structures|Thioesterase 3D structures]]
-Description: USP34 catalytic domain in complex with UbPA
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Xu, G.L]]
+__TOC__
-[[Category: Ming, Z.H]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Ming ZH]]
+[[Category: Xu GL]]