2cbq: Difference between revisions

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<StructureSection load='2cbq' size='340' side='right'caption='[[2cbq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2cbq' size='340' side='right'caption='[[2cbq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2cbq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/'streptomyces_carzinostaticus' 'streptomyces carzinostaticus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CBQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2cbq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CBQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH2:TESTOSTERONE+HEMISUCCINATE'>TH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j5h|1j5h]], [[1j5i|1j5i]], [[1kvh|1kvh]], [[1mp7|1mp7]], [[1nco|1nco]], [[1noa|1noa]], [[1o5p|1o5p]], [[2cbm|2cbm]], [[2cbo|2cbo]], [[2cbt|2cbt]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH2:TESTOSTERONE+HEMISUCCINATE'>TH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbq OCA], [https://pdbe.org/2cbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cbq RCSB], [https://www.ebi.ac.uk/pdbsum/2cbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cbq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbq OCA], [https://pdbe.org/2cbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cbq RCSB], [https://www.ebi.ac.uk/pdbsum/2cbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cbq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.  
[https://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces carzinostaticus]]
[[Category: Streptomyces carzinostaticus]]
[[Category: Large Structures]]
[[Category: Desmadril M]]
[[Category: Desmadril, M]]
[[Category: Drevelle A]]
[[Category: Drevelle, A]]
[[Category: Graille M]]
[[Category: Graille, M]]
[[Category: Heyd B]]
[[Category: Heyd, B]]
[[Category: Minard P]]
[[Category: Minard, P]]
[[Category: Pecorari F]]
[[Category: Pecorari, F]]
[[Category: Sorel I]]
[[Category: Sorel, I]]
[[Category: Ulryck N]]
[[Category: Tilbeurgh, H Van]]
[[Category: Van Tilbeurgh H]]
[[Category: Ulryck, N]]
[[Category: Antibiotic]]
[[Category: Antimicrobial]]
[[Category: Dna-binding]]
[[Category: Phage-display hapten binding]]
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