7w5q: Difference between revisions
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New page: '''Unreleased structure''' The entry 7w5q is ON HOLD Authors: Description: Category: Unreleased Structures |
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The | ==The Kruppel-associated box (KRAB) domain of human zinc finger protein 568== | ||
<StructureSection load='7w5q' size='340' side='right'caption='[[7w5q]], [[Resolution|resolution]] 2.73Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7w5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W5Q FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.73Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w5q OCA], [https://pdbe.org/7w5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w5q RCSB], [https://www.ebi.ac.uk/pdbsum/7w5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w5q ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ZN568_HUMAN ZN568_HUMAN] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.[UniProtKB:E9PYI1] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Han CW]] | |||
[[Category: Jang SB]] | |||
Latest revision as of 17:36, 29 November 2023
The Kruppel-associated box (KRAB) domain of human zinc finger protein 568
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