7w68: Difference between revisions
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==human single hexameric Mcm2-7 complex== | |||
<StructureSection load='7w68' size='340' side='right'caption='[[7w68]], [[Resolution|resolution]] 4.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7w68]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W68 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w68 OCA], [https://pdbe.org/7w68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w68 RCSB], [https://www.ebi.ac.uk/pdbsum/7w68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w68 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Lin | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/MCM4_HUMAN MCM4_HUMAN] Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency. The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MCM4_HUMAN MCM4_HUMAN] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.<ref>PMID:16899510</ref> <ref>PMID:9305914</ref> | ||
[[Category: Xu | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Lin QP]] | |||
[[Category: Liu CD]] | |||
[[Category: Tian HL]] | |||
[[Category: Xiang Y]] | |||
[[Category: Xu NN]] | |||
[[Category: Zhu G]] | |||
Latest revision as of 11:46, 30 October 2024
human single hexameric Mcm2-7 complex
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