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<StructureSection load='7lyj' size='340' side='right'caption='[[7lyj]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
<StructureSection load='7lyj' size='340' side='right'caption='[[7lyj]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7lyj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LYJ FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LYJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IRI:IRIDIUM+HEXAMMINE+ION'>IRI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IRI:IRIDIUM+HEXAMMINE+ION'>IRI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyj OCA], [https://pdbe.org/7lyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyj RCSB], [https://www.ebi.ac.uk/pdbsum/7lyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyj OCA], [https://pdbe.org/7lyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyj RCSB], [https://www.ebi.ac.uk/pdbsum/7lyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyj ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 A-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome, and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics.
Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot.,Jones CP, Ferre-D'Amare AR RNA. 2021 Nov 29. pii: rna.078825.121. doi: 10.1261/rna.078825.121. PMID:34845084<ref>PMID:34845084</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7lyj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Amare, A R.Ferre-D]]
[[Category: Ferre-D'Amare AR]]
[[Category: Jones, C P]]
[[Category: Jones CP]]
[[Category: Coronavirus]]
[[Category: Covid]]
[[Category: Frameshift]]
[[Category: Pseudoknot]]
[[Category: Rna]]
[[Category: Sar]]
[[Category: Severe acute respiratory syndrome]]
[[Category: Tetraloop]]
[[Category: Triple]]
[[Category: Virus]]

Latest revision as of 14:27, 13 August 2026

SARS-CoV-2 frameshifting pseudoknot RNA

7lyj, resolution 2.11Å

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