2jku: Difference between revisions

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<StructureSection load='2jku' size='340' side='right'caption='[[2jku]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='2jku' size='340' side='right'caption='[[2jku]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JKU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JKU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cqy|2cqy]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Propionyl-CoA_carboxylase Propionyl-CoA carboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.4.1.3 6.4.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jku OCA], [https://pdbe.org/2jku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jku RCSB], [https://www.ebi.ac.uk/pdbsum/2jku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jku ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jku OCA], [https://pdbe.org/2jku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jku RCSB], [https://www.ebi.ac.uk/pdbsum/2jku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jku ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/PCCA_HUMAN PCCA_HUMAN]] Defects in PCCA are the cause of propionic acidemia type I (PA-1) [MIM:[https://omim.org/entry/606054 606054]]. PA-1 is a life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein.<ref>PMID:10101253</ref> <ref>PMID:12559849</ref> <ref>PMID:15059621</ref> <ref>PMID:10329019</ref>
[https://www.uniprot.org/uniprot/PCCA_HUMAN PCCA_HUMAN] Defects in PCCA are the cause of propionic acidemia type I (PA-1) [MIM:[https://omim.org/entry/606054 606054]. PA-1 is a life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein.<ref>PMID:10101253</ref> <ref>PMID:12559849</ref> <ref>PMID:15059621</ref> <ref>PMID:10329019</ref>  
== Function ==
[https://www.uniprot.org/uniprot/PCCA_HUMAN PCCA_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Propionyl-CoA carboxylase]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C]]
[[Category: Bountra C]]
[[Category: Bountra, C]]
[[Category: Edwards A]]
[[Category: Delft, F von]]
[[Category: Filippakopoulos P]]
[[Category: Edwards, A]]
[[Category: Gravel RA]]
[[Category: Filippakopoulos, P]]
[[Category: Healy S]]
[[Category: Gravel, R A]]
[[Category: Kochan G]]
[[Category: Healy, S]]
[[Category: Murray JW]]
[[Category: Kochan, G]]
[[Category: Oppermann U]]
[[Category: Murray, J W]]
[[Category: Pilka ES]]
[[Category: Oppermann, U]]
[[Category: Roos AK]]
[[Category: Pilka, E S]]
[[Category: Wikstrom M]]
[[Category: Roos, A K]]
[[Category: Yue WW]]
[[Category: Wikstrom, M]]
[[Category: Von Delft F]]
[[Category: Yue, W W]]
[[Category: Atp-binding]]
[[Category: Biotin]]
[[Category: Disease mutation]]
[[Category: Ligase]]
[[Category: Mitochondrion]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Transit peptide]]
Retrieved from "https://proteopedia.org/2jku"