7t27: Difference between revisions
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==Structure of phage FBB1 anti-CBASS nuclease Acb1-3'3'-cGAMP complex in post reaction state== | |||
<StructureSection load='7t27' size='340' side='right'caption='[[7t27]], [[Resolution|resolution]] 1.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7t27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Erwinia_phage_FBB1 Erwinia phage FBB1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T27 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ECI:[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-2-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphoryl]oxymethyl]-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphinic+acid'>ECI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t27 OCA], [https://pdbe.org/7t27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t27 RCSB], [https://www.ebi.ac.uk/pdbsum/7t27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t27 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ACB1_BPFBB ACB1_BPFBB] Counteracts the host CBASS antiviral defense system. Phosphodiesterase that enables metal-independent hydrolysis of the host cyclic di- and trinucleotide CBASS signals such as 3'3'-cGAMP, 3'3'cUA, and 3'3'3'-cAAA (PubMed:35395152). Does not cleave cGG or cA4 (By similarity). Besides evasion of the CBASS system, might also enable evasion of the type III CRISPR systems that use cA3 signals (By similarity).[UniProtKB:P04533]<ref>PMID:35395152</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Erwinia phage FBB1]] | |||
[[Category: Large Structures]] | |||
[[Category: Hobbs SJ]] | |||
[[Category: Kranzusch PJ]] | |||
[[Category: Lu A]] | |||
[[Category: Morehouse BR]] | |||
[[Category: Schnabel J]] | |||
[[Category: Sorek R]] | |||
[[Category: Wein T]] | |||
Latest revision as of 13:06, 1 March 2024
Structure of phage FBB1 anti-CBASS nuclease Acb1-3'3'-cGAMP complex in post reaction state
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