7t7r: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 7t7r is ~~ON HOLD~~

==Structure of Munc13-1 C1-C2B-MUN-C2C trimer between lipid bilayers==

~~Authors~~: ~~Grushin~~, K., ~~Sindelar~~, C.V.

== Structural highlights ==

<table><tr><td colspan='2'>[[7t7r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7R FirstGlance]. <br>

~~Description~~: ~~Structure~~ of ~~Munc13~~-~~1 C1~~-~~C2B-MUN-C2C trimer between lipid bilayers~~

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7r OCA], [https://pdbe.org/7t7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7r RCSB], [https://www.ebi.ac.uk/pdbsum/7t7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7r ProSAT]</span></td></tr>

[[Category: ~~Sindelar, C.V~~]]

</table>

[[Category: Grushin, K]]

== Function ==

[https://www.uniprot.org/uniprot/UN13A_MOUSE UN13A_MOUSE] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (PubMed:23229896). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity).[UniProtKB:Q62768][UniProtKB:Q9UPW8]<ref>PMID:10440375</ref> <ref>PMID:12070347</ref> <ref>PMID:15988013</ref> <ref>PMID:16644700</ref> <ref>PMID:16697276</ref> <ref>PMID:17267576</ref> <ref>PMID:17639022</ref> <ref>PMID:23229896</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Grushin K]]

[[Category: Sindelar CV]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7t7r is ON HOLD
+==Structure of Munc13-1 C1-C2B-MUN-C2C trimer between lipid bilayers==
+<StructureSection load='7t7r' size='340' side='right'caption='[[7t7r]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
-Authors: Grushin, K., Sindelar, C.V.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7t7r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7R FirstGlance]. <br>
-Description: Structure of Munc13-1 C1-C2B-MUN-C2C trimer between lipid bilayers
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7r OCA], [https://pdbe.org/7t7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7r RCSB], [https://www.ebi.ac.uk/pdbsum/7t7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7r ProSAT]</span></td></tr>
-[[Category: Sindelar, C.V]]
+</table>
-[[Category: Grushin, K]]
+== Function ==
+[https://www.uniprot.org/uniprot/UN13A_MOUSE UN13A_MOUSE] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (PubMed:23229896). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity).[UniProtKB:Q62768][UniProtKB:Q9UPW8]<ref>PMID:10440375</ref> <ref>PMID:12070347</ref> <ref>PMID:15988013</ref> <ref>PMID:16644700</ref> <ref>PMID:16697276</ref> <ref>PMID:17267576</ref> <ref>PMID:17639022</ref> <ref>PMID:23229896</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Grushin K]]
+[[Category: Sindelar CV]]