7t7v: Difference between revisions
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New page: '''Unreleased structure''' The entry 7t7v is ON HOLD Authors: Grushin, K., Sindelar, C.V. Description: Munc13-1 C1-C2B-MUN-C2C Lateral conformation on lipid bilayer surface [[Category:... |
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==Munc13-1 C1-C2B-MUN-C2C Lateral conformation on lipid bilayer surface== | |||
<StructureSection load='7t7v' size='340' side='right'caption='[[7t7v]], [[Resolution|resolution]] 10.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7t7v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7V FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7v OCA], [https://pdbe.org/7t7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7v RCSB], [https://www.ebi.ac.uk/pdbsum/7t7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7v ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Grushin | == Function == | ||
[https://www.uniprot.org/uniprot/UN13A_MOUSE UN13A_MOUSE] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (PubMed:23229896). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity).[UniProtKB:Q62768][UniProtKB:Q9UPW8]<ref>PMID:10440375</ref> <ref>PMID:12070347</ref> <ref>PMID:15988013</ref> <ref>PMID:16644700</ref> <ref>PMID:16697276</ref> <ref>PMID:17267576</ref> <ref>PMID:17639022</ref> <ref>PMID:23229896</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Grushin K]] | |||
[[Category: Sindelar CV]] | |||
Latest revision as of 13:07, 1 March 2024
Munc13-1 C1-C2B-MUN-C2C Lateral conformation on lipid bilayer surface
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