3a98: Difference between revisions

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<StructureSection load='3a98' size='340' side='right'caption='[[3a98]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3a98' size='340' side='right'caption='[[3a98]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3a98]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A98 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3a98]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A98 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOCK2, KIAA0209 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ELMO1, KIAA0281 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a98 OCA], [https://pdbe.org/3a98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a98 RCSB], [https://www.ebi.ac.uk/pdbsum/3a98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a98 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a98 OCA], [https://pdbe.org/3a98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a98 RCSB], [https://www.ebi.ac.uk/pdbsum/3a98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a98 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DOCK2_HUMAN DOCK2_HUMAN]] Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.<ref>PMID:21613211</ref> [[https://www.uniprot.org/uniprot/ELMO1_HUMAN ELMO1_HUMAN]] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.<ref>PMID:11595183</ref> <ref>PMID:12134158</ref> 
[https://www.uniprot.org/uniprot/DOCK2_HUMAN DOCK2_HUMAN] Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.<ref>PMID:21613211</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
*[[Engulfment and cell motility protein 1|Engulfment and cell motility protein 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fukui, Y]]
[[Category: Fukui Y]]
[[Category: Hanawa-Suetsugu, K]]
[[Category: Hanawa-Suetsugu K]]
[[Category: Ito, T]]
[[Category: Ito T]]
[[Category: Kukimoto-Niino, M]]
[[Category: Kukimoto-Niino M]]
[[Category: Mishima-Tsumagari, C]]
[[Category: Mishima-Tsumagari C]]
[[Category: Sekine, S]]
[[Category: Sekine S]]
[[Category: Shirouzu, M]]
[[Category: Shirouzu M]]
[[Category: Terada, T]]
[[Category: Terada T]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: Apoptosis]]
[[Category: Cell membrane]]
[[Category: Cytoskeleton]]
[[Category: Dock2]]
[[Category: Elmo1]]
[[Category: Guanine-nucleotide releasing factor]]
[[Category: Helix bundle]]
[[Category: Membrane]]
[[Category: Ph domain]]
[[Category: Phagocytosis]]
[[Category: Phosphoprotein]]
[[Category: Proline-rich sequence]]
[[Category: Protein-protein complex]]
[[Category: Sh3 domain]]
[[Category: Sh3-binding]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/3a98"