7f80: Difference between revisions

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'''Unreleased structure'''


The entry 7f80 is ON HOLD  until Paper Publication
==Co-crystal structure of Inhibitor compound MA-211 in complex with human PPARdelta LBD==
<StructureSection load='7f80' size='340' side='right'caption='[[7f80]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7f80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F80 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KF:(3R)-3-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethyl)phenyl]imidazol-1-yl]methyl]phenoxy]hexanoic+acid'>1KF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f80 OCA], [https://pdbe.org/7f80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f80 RCSB], [https://www.ebi.ac.uk/pdbsum/7f80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f80 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>


Authors: Lakshminarasimhan, A., Rani, S.T., Senaiar, R.S., Krishnamurthy, N.
==See Also==
 
*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
Description: Co-crystal structure of Inhibitor compound MA-211 in complex with human PPARdelta LBD
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Senaiar, R.S]]
__TOC__
[[Category: Krishnamurthy, N]]
</StructureSection>
[[Category: Lakshminarasimhan, A]]
[[Category: Homo sapiens]]
[[Category: Rani, S.T]]
[[Category: Large Structures]]
[[Category: Krishnamurthy N]]
[[Category: Lakshminarasimhan A]]
[[Category: Rani ST]]
[[Category: Senaiar RS]]
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