7qnk: Difference between revisions
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==Structure of beta-lactamase TEM-171 complexed with tazobactam intermediate at 2.5 A resolution== | |||
<StructureSection load='7qnk' size='340' side='right'caption='[[7qnk]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7qnk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QNK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=TBE:TAZOBACTAM+INTERMEDIATE'>TBE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qnk OCA], [https://pdbe.org/7qnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qnk RCSB], [https://www.ebi.ac.uk/pdbsum/7qnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qnk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors. | |||
==See Also== | |||
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: Egorov | [[Category: Large Structures]] | ||
[[Category: Hakanpaa | [[Category: Egorov AM]] | ||
[[Category: | [[Category: Hakanpaa J]] | ||
[[Category: | [[Category: Lamzin VS]] | ||
[[Category: Petrova T]] | |||
[[Category: Samygina VR]] | |||
Latest revision as of 13:20, 1 February 2024
Structure of beta-lactamase TEM-171 complexed with tazobactam intermediate at 2.5 A resolution
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