7w6s: Difference between revisions

Latest revision as of 06:38, 25 June 2025

CryoEM structure of human KChIP2-Kv4.3 complex

Structural highlights

7w6s is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KCIP2_HUMAN Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220). Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220). Involved in KCND2 and KCND3 trafficking to the cell surface (PubMed:12829703). May be required for the expression of I(To) currents in the heart (By similarity).[UniProtKB:Q9JJ69]^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7]

References

↑ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ. Modulation of A-type potassium channels by a family of calcium sensors. Nature. 2000 Feb 3;403(6769):553-6. PMID:10676964 doi:10.1038/35000592
↑ Bahring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D. Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. J Biol Chem. 2001 Jun 29;276(26):23888-94. Epub 2001 Apr 3. PMID:11287421 doi:https://dx.doi.org/10.1074/jbc.M101320200
↑ Decher N, Uyguner O, Scherer CR, Karaman B, Yuksel-Apak M, Busch AE, Steinmeyer K, Wollnik B. hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant. Cardiovasc Res. 2001 Nov;52(2):255-64. PMID:11684073
↑ Deschenes I, Tomaselli GF. Modulation of Kv4.3 current by accessory subunits. FEBS Lett. 2002 Sep 25;528(1-3):183-8. doi: 10.1016/s0014-5793(02)03296-9. PMID:12297301 doi:https://dx.doi.org/10.1016/s0014-5793(02)03296-9
↑ Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. J Biol Chem. 2003 Sep 19;278(38):36445-54. Epub 2003 Jun 26. PMID:12829703 doi:10.1074/jbc.M306142200
↑ Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA. Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. J Biol Chem. 2004 Feb 13;279(7):5549-54. doi: 10.1074/jbc.M311332200. Epub 2003, Nov 17. PMID:14623880 doi:https://dx.doi.org/10.1074/jbc.M311332200
↑ Ma D, Zhao C, Wang X, Li X, Zha Y, Zhang Y, Fu G, Liang P, Guo J, Lai D. Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res. 2022 Apr;32(4):411-414. PMID:34997220 doi:10.1038/s41422-021-00608-4

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OCA

[1] An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ. Modulation of A-type potassium channels by a family of calcium sensors. Nature. 2000 Feb 3;403(6769):553-6. PMID:10676964 doi:10.1038/35000592

[2] Bahring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D. Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. J Biol Chem. 2001 Jun 29;276(26):23888-94. Epub 2001 Apr 3. PMID:11287421 doi:https://dx.doi.org/10.1074/jbc.M101320200

[3] Decher N, Uyguner O, Scherer CR, Karaman B, Yuksel-Apak M, Busch AE, Steinmeyer K, Wollnik B. hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant. Cardiovasc Res. 2001 Nov;52(2):255-64. PMID:11684073

[4] Deschenes I, Tomaselli GF. Modulation of Kv4.3 current by accessory subunits. FEBS Lett. 2002 Sep 25;528(1-3):183-8. doi: 10.1016/s0014-5793(02)03296-9. PMID:12297301 doi:https://dx.doi.org/10.1016/s0014-5793(02)03296-9

[5] Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. J Biol Chem. 2003 Sep 19;278(38):36445-54. Epub 2003 Jun 26. PMID:12829703 doi:10.1074/jbc.M306142200

[6] Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA. Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. J Biol Chem. 2004 Feb 13;279(7):5549-54. doi: 10.1074/jbc.M311332200. Epub 2003, Nov 17. PMID:14623880 doi:https://dx.doi.org/10.1074/jbc.M311332200

[7] Ma D, Zhao C, Wang X, Li X, Zha Y, Zhang Y, Fu G, Liang P, Guo J, Lai D. Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res. 2022 Apr;32(4):411-414. PMID:34997220 doi:10.1038/s41422-021-00608-4

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7w6s is ON HOLD  until Paper Publication
+==CryoEM structure of human KChIP2-Kv4.3 complex==
+<StructureSection load='7w6s' size='340' side='right'caption='[[7w6s]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7w6s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W6S FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w6s OCA], [https://pdbe.org/7w6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w6s RCSB], [https://www.ebi.ac.uk/pdbsum/7w6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w6s ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KCIP2_HUMAN KCIP2_HUMAN] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220). Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220). Involved in KCND2 and KCND3 trafficking to the cell surface (PubMed:12829703). May be required for the expression of I(To) currents in the heart (By similarity).[UniProtKB:Q9JJ69]<ref>PMID:10676964</ref> <ref>PMID:11287421</ref> <ref>PMID:11684073</ref> <ref>PMID:12297301</ref> <ref>PMID:12829703</ref> <ref>PMID:14623880</ref> <ref>PMID:34997220</ref>
-Authors:
+==See Also==
+*[[Potassium channel 3D structures|Potassium channel 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Guo JT]]
+[[Category: Ma DM]]

7w6s: Difference between revisions

Latest revision as of 06:38, 25 June 2025

CryoEM structure of human KChIP2-Kv4.3 complex

Structural highlights

Function

See Also

References

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