7wf4: Difference between revisions

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'''Unreleased structure'''


The entry 7wf4 is ON HOLD
==Composite map of human Kv1.3 channel in dalazatide-bound state with beta subunits==
<StructureSection load='7wf4' size='340' side='right'caption='[[7wf4]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7wf4]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WF4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wf4 OCA], [https://pdbe.org/7wf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wf4 RCSB], [https://www.ebi.ac.uk/pdbsum/7wf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wf4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCNA3_HUMAN KCNA3_HUMAN] Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report two structures of the human voltage-gated potassium channel (Kv) Kv1.3 in immune cells alone (apo-Kv1.3) and bound to an immunomodulatory drug called dalazatide (dalazatide-Kv1.3). Both the apo-Kv1.3 and dalazatide-Kv1.3 structures are in an activated state based on their depolarized voltage sensor and open inner gate. In apo-Kv1.3, the aromatic residue in the signature sequence (Y447) adopts a position that diverges 11 A from other K(+) channels. The outer pore is significantly rearranged, causing widening of the selectivity filter and perturbation of ion binding within the filter. This conformation is stabilized by a network of intrasubunit hydrogen bonds. In dalazatide-Kv1.3, binding of dalazatide to the channel's outer vestibule narrows the selectivity filter, Y447 occupies a position seen in other K(+) channels, and this conformation is stabilized by a network of intersubunit hydrogen bonds. These remarkable rearrangements in the selectivity filter underlie Kv1.3's transition into the drug-blocked state.


Authors: Tyagi, A., Ahmed, T., Jian, S., Bajaj, S., Ong, S.T., Goay, S.S.M., Zhao, Y., Vorobyov, I., Tian, C., Chandy, K.G., Bhushan, S.
Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.,Tyagi A, Ahmed T, Jian S, Bajaj S, Ong ST, Goay SSM, Zhao Y, Vorobyov I, Tian C, Chandy KG, Bhushan S Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2113536119. doi: , 10.1073/pnas.2113536119. PMID:35091471<ref>PMID:35091471</ref>


Description: Composite map of human Kv1.3 channel in dalazatide-bound state with beta subunits
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Bajaj, S]]
<div class="pdbe-citations 7wf4" style="background-color:#fffaf0;"></div>
[[Category: Tyagi, A]]
 
[[Category: Goay, S.S.M]]
==See Also==
[[Category: Jian, S]]
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
[[Category: Vorobyov, I]]
== References ==
[[Category: Tian, C]]
<references/>
[[Category: Bhushan, S]]
__TOC__
[[Category: Chandy, K.G]]
</StructureSection>
[[Category: Ong, S.T]]
[[Category: Homo sapiens]]
[[Category: Ahmed, T]]
[[Category: Large Structures]]
[[Category: Zhao, Y]]
[[Category: Ahmed T]]
[[Category: Bajaj S]]
[[Category: Bhushan S]]
[[Category: Chandy KG]]
[[Category: Goay SSM]]
[[Category: Jian S]]
[[Category: Ong ST]]
[[Category: Tian C]]
[[Category: Tyagi A]]
[[Category: Vorobyov I]]
[[Category: Zhao Y]]
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