2gx1: Difference between revisions

<StructureSection load='2gx1' size='340' side='right'caption='[[2gx1]]' scene=''>

<table><tr><td colspan='2'>[[2gx1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrothele_gigas Macrothele gigas]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GX1 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gx1 OCA], [https://pdbe.org/2gx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gx1 RCSB], [https://www.ebi.ac.uk/pdbsum/2gx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gx1 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TXMG5_MACGS TXMG5_MACGS] Insect and vertebrate active toxin. Binds to site 4 of mammalian voltage-gated sodium channels and shifts the activation voltage of the mammalian Nav1.2a/SCN2A channel to more hyperpolarized voltages, whereas the insect channel, DmNav1 (para), is not affected. Competes for binding at site 3 of the insect sodium channel. Causes temporary paralysis when injected into lepidopteran larvae at 8.6 nmol/g. A low intracranial injection dose into mice causes lacrimation, closure of the eyes and sweating. A high injection dose causes extensive lacrimation and death.<ref>PMID:12860384</ref>  

[[Category: Billen B]]

[[Category: Bosmans F]]

[[Category: Corzo G]]

[[Category: Norton RS]]

[[Category: Sabo JK]]

[[Category: Tytgat J]]

[[Category: Villegas E]]