7qq4: Difference between revisions
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==Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate== | |||
<StructureSection load='7qq4' size='340' side='right'caption='[[7qq4]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7qq4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QQ4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EIK:5,8-dimethyl-2-[2-(1-methyl-4-phenyl-imidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine'>EIK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Langgard | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qq4 OCA], [https://pdbe.org/7qq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qq4 RCSB], [https://www.ebi.ac.uk/pdbsum/7qq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qq4 ProSAT]</span></td></tr> | ||
[[Category: Leonard | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Langgard M]] | |||
[[Category: Leonard PM]] | |||
Latest revision as of 07:58, 7 February 2024
Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate
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