7t91: Difference between revisions
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==Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region== | |||
<StructureSection load='7t91' size='340' side='right'caption='[[7t91]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7t91]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T91 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t91 OCA], [https://pdbe.org/7t91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t91 RCSB], [https://www.ebi.ac.uk/pdbsum/7t91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t91 ProSAT]</span></td></tr> | ||
[[Category: Augelli-Szanfran | </table> | ||
[[Category: Boohaker | == Function == | ||
[[Category: Zhang | [https://www.uniprot.org/uniprot/GLI1_HUMAN GLI1_HUMAN] Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.<ref>PMID:10806483</ref> <ref>PMID:11238441</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Augelli-Szanfran CE]] | |||
[[Category: Boohaker RJ]] | |||
[[Category: Wu M]] | |||
[[Category: Zhang S]] | |||
Latest revision as of 09:44, 25 October 2023
Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region
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