6y14: Difference between revisions

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<StructureSection load='6y14' size='340' side='right'caption='[[6y14]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
<StructureSection load='6y14' size='340' side='right'caption='[[6y14]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6y14]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y14 FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y14 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=O65:3,5-bis(hydroxymethyl)-4-methyl-benzaldehyde'>O65</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.9&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=O65:3,5-bis(hydroxymethyl)-4-methyl-benzaldehyde'>O65</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y14 OCA], [https://pdbe.org/6y14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y14 RCSB], [https://www.ebi.ac.uk/pdbsum/6y14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y14 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y14 OCA], [https://pdbe.org/6y14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y14 RCSB], [https://www.ebi.ac.uk/pdbsum/6y14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y14 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The peptide alpha-helix is right-handed when containing amino acids with l-chirality, and left-handed with d-chirality, however mixed chirality peptides generally do not form alpha-helices unless a helix inducer such as the non-natural residue amino-isobutyric acid is used. Herein we report the first X-ray crystal structures of mixed chirality alpha-helices in short peptides comprising only natural residues as the example of a stapled bicyclic and a linear membrane disruptive amphiphilic antimicrobial peptide (AMP) containing seven l- and four d-residues, as complexes of fucosylated analogs with the bacterial lectin LecB. The mixed chirality alpha-helices are superimposable onto the homochiral alpha-helices and form under similar conditions as shown by CD spectra and MD simulations but non-hemolytic and resistant to proteolysis. The observation of a mixed chirality alpha-helix with only natural residues in the protein environment of LecB suggests a vast unexplored territory of alpha-helical mixed chirality sequences and their possible use for optimizing bioactive alpha-helical peptides.
A mixed chirality alpha-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography.,Baeriswyl S, Personne H, Di Bonaventura I, Kohler T, van Delden C, Stocker A, Javor S, Reymond JL RSC Chem Biol. 2021 Aug 20;2(6):1608-1617. doi: 10.1039/d1cb00124h. eCollection, 2021 Dec 2. PMID:34977576<ref>PMID:34977576</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6y14" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Baeriswyl, S]]
[[Category: Baeriswyl S]]
[[Category: Reymond, J L]]
[[Category: Reymond J-L]]
[[Category: Stocker, A]]
[[Category: Stocker A]]
[[Category: Antibiotic]]
[[Category: Antimicrobial]]
[[Category: Bicyclic]]
[[Category: Stapled]]

Latest revision as of 10:43, 23 October 2024

Bicyclic peptide bp65 crystallized as racemic mixture at 0.9 Angstrom resolution

6y14, resolution 0.90Å

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