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==Structure of a (3+1) G-quadruplex formed by hTERT promoter sequence==
==Structure of a (3+1) G-quadruplex formed by hTERT promoter sequence==
<StructureSection load='2kzd' size='340' side='right'caption='[[2kzd]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2kzd' size='340' side='right'caption='[[2kzd]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kzd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kzd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZD FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI:2-DEOXYINOSINE-5-MONOPHOSPHATE'>DI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kze|2kze]], [[2a5p|2a5p]], [[2o3m|2o3m]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzd OCA], [https://pdbe.org/2kzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzd RCSB], [https://www.ebi.ac.uk/pdbsum/2kzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzd OCA], [https://pdbe.org/2kzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzd RCSB], [https://www.ebi.ac.uk/pdbsum/2kzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzd ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The catalytic subunit of human telomerase, hTERT, actively elongates the 3' end of the telomere in most cancer cells. The hTERT promoter, which contains many guanine-rich stretches on the same DNA strand, exhibits an exceptional potential for G-quadruplex formation. Here we show that one particular G-rich sequence in this region coexists in two G-quadruplex conformations in potassium solution: a (3 + 1) and a parallel-stranded G-quadruplexes. We present the NMR solution structures of both conformations, each comprising several robust structural elements, among which include the (3 + 1) and all-parallel G-tetrad cores, single-residue double-chain-reversal loops, and a capping A.T base pair. A combination of NMR and CD techniques, complemented with sequence modifications and variations of experimental condition, allowed us to better understand the coexistence of the two G-quadruplex conformations in equilibrium and how different structural elements conspire to favor a particular form.
Coexistence of two distinct G-quadruplex conformations in the hTERT promoter.,Lim KW, Lacroix L, Yue DJ, Lim JK, Lim JM, Phan AT J Am Chem Soc. 2010 Sep 8;132(35):12331-42. PMID:20704263<ref>PMID:20704263</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2kzd" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lacroix, L]]
[[Category: Lacroix L]]
[[Category: Lim, J K.C]]
[[Category: Lim JKC]]
[[Category: Lim, J M.W]]
[[Category: Lim JMW]]
[[Category: Lim, K W]]
[[Category: Lim KW]]
[[Category: Phan, A T]]
[[Category: Phan AT]]
[[Category: Yue, D J.E]]
[[Category: Yue DJE]]
[[Category: Anticancer target]]
[[Category: Dna]]
[[Category: G-quadruplex]]
[[Category: Htert promoter]]
[[Category: Telomerase inhibition]]

Latest revision as of 06:50, 1 May 2024

Structure of a (3+1) G-quadruplex formed by hTERT promoter sequence

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