7tre: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 7tre is ~~ON HOLD~~

==Human telomerase catalytic core with shelterin protein TPP1==

== Structural highlights ==

<table><tr><td colspan='2'>[[7tre]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRE FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tre OCA], [https://pdbe.org/7tre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tre RCSB], [https://www.ebi.ac.uk/pdbsum/7tre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tre ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/ACD_HUMAN ACD_HUMAN] Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.<ref>PMID:15181449</ref> <ref>PMID:16166375</ref> <ref>PMID:16880378</ref> <ref>PMID:20231318</ref> <ref>PMID:17237768</ref>

~~Authors: Liu, B., He, Y., Wang, Y., Song, H., Zhou, Z.H., Feigon, J.~~

==See Also==

*[[Telomerase 3D structures|Telomerase 3D structures]]

~~Description~~: ~~Human telomerase catalytic core structure with shelterin protein TPP1~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: Feigon, J]]

__TOC__

[[Category: ~~Zhou, Z.H~~]]

</StructureSection>

[[Category: ~~Song, H~~]]

[[Category: Homo sapiens]]

[[Category: ~~He, Y~~]]

[[Category: Large Structures]]

[[Category: Wang, Y]]

[[Category: Feigon J]]

[[Category: ~~Liu, B~~]]

[[Category: He Y]]

[[Category: Liu B]]

[[Category: Song H]]

[[Category: Wang Y]]

[[Category: Zhou ZH]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7tre is ON HOLD
+==Human telomerase catalytic core with shelterin protein TPP1==
+<StructureSection load='7tre' size='340' side='right'caption='[[7tre]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7tre]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRE FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tre OCA], [https://pdbe.org/7tre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tre RCSB], [https://www.ebi.ac.uk/pdbsum/7tre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tre ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ACD_HUMAN ACD_HUMAN] Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.<ref>PMID:15181449</ref> <ref>PMID:16166375</ref> <ref>PMID:16880378</ref> <ref>PMID:20231318</ref> <ref>PMID:17237768</ref>
-Authors: Liu, B., He, Y., Wang, Y., Song, H., Zhou, Z.H., Feigon, J.
+==See Also==
+*[[Telomerase 3D structures|Telomerase 3D structures]]
-Description: Human telomerase catalytic core structure with shelterin protein TPP1
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Feigon, J]]
+__TOC__
-[[Category: Zhou, Z.H]]
+</StructureSection>
-[[Category: Song, H]]
+[[Category: Homo sapiens]]
-[[Category: He, Y]]
+[[Category: Large Structures]]
-[[Category: Wang, Y]]
+[[Category: Feigon J]]
-[[Category: Liu, B]]
+[[Category: He Y]]
+[[Category: Liu B]]
+[[Category: Song H]]
+[[Category: Wang Y]]
+[[Category: Zhou ZH]]