7wh4: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of the PadR-family transcriptional regulator Rv3488 of Mycobacterium tuberculosis H37Rv in complex with Manganese ion== | ==Crystal structure of the PadR-family transcriptional regulator Rv3488 of Mycobacterium tuberculosis H37Rv in complex with Manganese ion== | ||
<StructureSection load='7wh4' size='340' side='right'caption='[[7wh4]]' scene=''> | <StructureSection load='7wh4' size='340' side='right'caption='[[7wh4]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WH4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7wh4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WH4 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wh4 OCA], [https://pdbe.org/7wh4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wh4 RCSB], [https://www.ebi.ac.uk/pdbsum/7wh4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wh4 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wh4 OCA], [https://pdbe.org/7wh4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wh4 RCSB], [https://www.ebi.ac.uk/pdbsum/7wh4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wh4 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CDDTR_MYCTU CDDTR_MYCTU] May have transcription regulation and metal-detoxifying functions through which it may enhance intracellular survival of mycobacteria. Binds to its own promoter region and to the Rv1999c promoter region. It displays strong affinity for cadmium ions, but can also bind zinc, manganese and nickel. Expression increases the intracellular survival of recombinant M. smegmatis in murine macrophage cell line and increases its tolerance to cadmium ions.<ref>PMID:30266832</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Arora A]] | [[Category: Arora A]] | ||
[[Category: Biswal BK]] | [[Category: Biswal BK]] | ||
[[Category: Pal RK]] | [[Category: Pal RK]] | ||
[[Category: Zohib M]] | [[Category: Zohib M]] | ||
Latest revision as of 17:40, 29 November 2023
Crystal structure of the PadR-family transcriptional regulator Rv3488 of Mycobacterium tuberculosis H37Rv in complex with Manganese ion
| ||||||||||||
