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==haddock model of GATA1NF:Lmo2LIM2-Ldb1LID==
==haddock model of GATA1NF:Lmo2LIM2-Ldb1LID==
<StructureSection load='2l6y' size='340' side='right'caption='[[2l6y]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2l6y' size='340' side='right'caption='[[2l6y]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2l6y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L6Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[2l6y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L6Y FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2l6z|2l6z]], [[2l3k|2l3k]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6y OCA], [https://pdbe.org/2l6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l6y RCSB], [https://www.ebi.ac.uk/pdbsum/2l6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l6y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6y OCA], [https://pdbe.org/2l6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l6y RCSB], [https://www.ebi.ac.uk/pdbsum/2l6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l6y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GATA1_MOUSE GATA1_MOUSE]] Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells.<ref>PMID:2276623</ref> <ref>PMID:8206977</ref> <ref>PMID:8524811</ref> <ref>PMID:15173587</ref> <ref>PMID:16888089</ref> 
[https://www.uniprot.org/uniprot/GATA1_MOUSE GATA1_MOUSE] Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells.<ref>PMID:2276623</ref> <ref>PMID:8206977</ref> <ref>PMID:8524811</ref> <ref>PMID:15173587</ref> <ref>PMID:16888089</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The control of red blood cell and megakaryocyte development by the regulatory protein GATA1 is a paradigm for transcriptional regulation of gene expression in cell lineage differentiation and maturation. Most GATA1-regulated events require GATA1 to bind FOG1, and essentially all GATA1-activated genes are cooccupied by a TAL1/E2A/LMO2/LDB1 complex; however, it is not known whether FOG1 and TAL1/E2A/LMO2/LDB1 are simultaneously recruited by GATA1. Our structural data reveal that the FOG1-binding domain of GATA1, the N finger, can also directly contact LMO2 and show that, despite the small size (&lt; 50 residues) of the GATA1 N finger, both FOG1 and LMO2 can simultaneously bind this domain. LMO2 in turn can simultaneously contact both GATA1 and the DNA-binding protein TAL1/E2A at bipartite E-box/WGATAR sites. Taken together, our data provide the first structural snapshot of multiprotein complex formation at GATA1-dependent genes and support a model in which FOG1 and TAL1/E2A/LMO2/LDB1 can cooccupy E-box/WGATAR sites to facilitate GATA1-mediated activation of gene activation.
 
Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1.,Wilkinson-White L, Gamsjaeger R, Dastmalchi S, Wienert B, Stokes PH, Crossley M, Mackay JP, Matthews JM Proc Natl Acad Sci U S A. 2011 Aug 15. PMID:21844373<ref>PMID:21844373</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2l6y" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Crossley, M]]
[[Category: Crossley M]]
[[Category: Dastmalchi, S]]
[[Category: Dastmalchi S]]
[[Category: Gamsjaeger, R]]
[[Category: Gamsjaeger R]]
[[Category: Mackay, J P]]
[[Category: Mackay JP]]
[[Category: Matthews, J M]]
[[Category: Matthews JM]]
[[Category: Stokes, P H]]
[[Category: Stokes PH]]
[[Category: Wienert, B]]
[[Category: Wienert B]]
[[Category: Wilkinson-White, L]]
[[Category: Wilkinson-White L]]
[[Category: Fog-1]]
[[Category: Gata-1]]
[[Category: Ldb1]]
[[Category: Lmo2]]
[[Category: Transcription regulation-oncoprotein complex]]

Latest revision as of 06:53, 1 May 2024

haddock model of GATA1NF:Lmo2LIM2-Ldb1LID

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