LRRK2: Difference between revisions
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== LRRK2 == | == LRRK2 == | ||
<p>This multidomain protein called '''LRRK2''' or '''dardarin''' or '''leucine-rich repeat serine/threonine-protein kinase 2''' is a product of LRRK2 gene. Its abbreviation stands for leucine rich repeat kinase 2 and it belongs to ROCO protein family (see also [[Serine/threonine protein kinase]]). Although its precise function is unknown, it is proposed that LRRK2 interacts with microtubules, phosphorylates Rab GTPase which marks membranous cargos moving along the microtubules, phosphorylates β-tubulin, moesin, FoxO1, tau, and others <ref>PMID:24725412</ref>. The cargo might be implicated in pathology of Parkinson´s disease <ref>PMID: 27830778</ref>.</p> | <p>This multidomain protein called '''LRRK2''' or '''dardarin''' or '''leucine-rich repeat serine/threonine-protein kinase 2''' or '''non-specific serine/threonine-protein kinase''' is a product of LRRK2 gene. Its abbreviation stands for leucine rich repeat kinase 2 and it belongs to ROCO protein family (see also [[Serine/threonine protein kinase]]). Although its precise function is unknown, it is proposed that LRRK2 interacts with microtubules, phosphorylates Rab GTPase which marks membranous cargos moving along the microtubules, phosphorylates β-tubulin, moesin, FoxO1, tau, and others <ref>PMID:24725412</ref>. The cargo might be implicated in pathology of Parkinson´s disease <ref>PMID: 27830778</ref>.</p> | ||
<p>LRRK2 is 2527 amino acids long protein in which we can distinguish N-terminus with scaffold domains such as armadillo, ankyrin, and leucin-rich repeats interaction motifs, and C-terminus with Ras-like GTPase (ROC domain controlling kinase activity of LRRK2), MAPKKK-like kinase domain, COR domain important for dimerization, and scaffold WD40 domain<ref>PMID: 32814344</ref>. LRRK2 has both GTPase and kinase activity, mediated by ROC domain and kinase domain, respectively, and the kinase activity is regulated by the ROC domain <ref name="sest">PMID: 17706965</ref>.</p> | <p>LRRK2 is 2527 amino acids long protein in which we can distinguish N-terminus with scaffold domains such as armadillo, ankyrin, and leucin-rich repeats interaction motifs, and C-terminus with Ras-like GTPase (ROC domain controlling kinase activity of LRRK2), MAPKKK-like kinase domain, COR domain important for dimerization, and scaffold WD40 domain<ref>PMID: 32814344</ref>. LRRK2 has both GTPase and kinase activity, mediated by ROC domain and kinase domain, respectively, and the kinase activity is regulated by the ROC domain <ref name="sest">PMID: 17706965</ref>.</p> | ||
<p>COR domain represents a central part in head-to-head orientation when LRRK2 folds into predominant form of globular dimer, where kinase-WD40 modul folds back to domains of N-terminus and thus allows these parts to interact and create autophosphorylation sites <ref name="guaitoli"/>.</p> | <p>COR domain represents a central part in head-to-head orientation when LRRK2 folds into predominant form of globular dimer, where kinase-WD40 modul folds back to domains of N-terminus and thus allows these parts to interact and create autophosphorylation sites <ref name="guaitoli"/>.</p> | ||
