7r2i: Difference between revisions
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New page: '''Unreleased structure''' The entry 7r2i is ON HOLD Authors: Silva, D.O., Graedler, U., Bandeiras, T.M. Description: Human Cyclophilin D in complex with fragment [[Category: Unrelease... |
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==Human Cyclophilin D in complex with fragment== | |||
<StructureSection load='7r2i' size='340' side='right'caption='[[7r2i]], [[Resolution|resolution]] 1.31Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7r2i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R2I FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.31Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=UPZ:ethyl+7-methyl-2-oxidanylidene-1~{H}-pyrazolo[1,5-a]pyrimidine-6-carboxylate'>UPZ</scene></td></tr> | ||
[[Category: Bandeiras | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r2i OCA], [https://pdbe.org/7r2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r2i RCSB], [https://www.ebi.ac.uk/pdbsum/7r2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r2i ProSAT]</span></td></tr> | ||
[[Category: Graedler | </table> | ||
[[Category: Silva | == Function == | ||
[https://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bandeiras TM]] | |||
[[Category: Graedler U]] | |||
[[Category: Silva DO]] | |||
Latest revision as of 16:14, 1 April 2026
Human Cyclophilin D in complex with fragment
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