1f3c: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
==REFINED SOLUTION STRUCTURE OF 8KDA DYNEIN LIGHT CHAIN (DLC8)== | ==REFINED SOLUTION STRUCTURE OF 8KDA DYNEIN LIGHT CHAIN (DLC8)== | ||
<StructureSection load='1f3c' size='340' side='right'caption='[[1f3c | <StructureSection load='1f3c' size='340' side='right'caption='[[1f3c]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1f3c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1f3c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bkq 1bkq]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F3C FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f3c OCA], [https://pdbe.org/1f3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f3c RCSB], [https://www.ebi.ac.uk/pdbsum/1f3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f3c ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f3c OCA], [https://pdbe.org/1f3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f3c RCSB], [https://www.ebi.ac.uk/pdbsum/1f3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f3c ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DYL1_RAT DYL1_RAT] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 (By similarity). Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 34: | Line 35: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Fan | [[Category: Rattus norvegicus]] | ||
[[Category: Tochio | [[Category: Fan J-S]] | ||
[[Category: Zhang | [[Category: Tochio H]] | ||
[[Category: Zhang | [[Category: Zhang M]] | ||
[[Category: Zhang Q]] | |||
