7fif: Difference between revisions

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<StructureSection load='7fif' size='340' side='right'caption='[[7fif]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
<StructureSection load='7fif' size='340' side='right'caption='[[7fif]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7fif]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hypdu Hypdu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FIF FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FIF FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BV898_06340 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=232323 HYPDU])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fif OCA], [https://pdbe.org/7fif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fif RCSB], [https://www.ebi.ac.uk/pdbsum/7fif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fif ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fif OCA], [https://pdbe.org/7fif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fif RCSB], [https://www.ebi.ac.uk/pdbsum/7fif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fif ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The evolutionarily conserved Hedgehog (Hh) signaling pathway is crucial for programmed cell differentiation and proliferation. Dispatched (Disp) is a 12-transmembrane protein that plays a critical role in the Hedgehog (Hh) signaling pathway by releasing the dually lipidated ligand HhN from the membrane, a prerequisite step to the downstream signaling cascade. In this study, we focus on the Disp from water bear, a primitive animal known as the most indestructible on Earth. Using a zebrafish model, we show that the water bear homolog possesses the function of Disp. We have solved its structure to a 6.5-A resolution using single-particle cryogenic electron microscopy. Consistent with the evolutional conservation of the pathway, the water bear Disp structure is overall similar to the previously reported structures of the fruit fly and human homologs. Although not revealing much detail at this resolution, the water bear Disp shows a different conformation compared to published structures, suggesting that they represent different functional snapshots.
Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release.,Luo Y, Wan G, Zhou X, Wang Q, Zhang Y, Bao J, Cong Y, Zhao Y, Li D Front Mol Biosci. 2021 Sep 7;8:701826. doi: 10.3389/fmolb.2021.701826., eCollection 2021. PMID:34557519<ref>PMID:34557519</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7fif" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hypdu]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cong, Y]]
[[Category: Cong Y]]
[[Category: Li, D]]
[[Category: Li D]]
[[Category: Luo, Y]]
[[Category: Luo Y]]
[[Category: Wan, G]]
[[Category: Wan G]]
[[Category: Wang, Q]]
[[Category: Wang Q]]
[[Category: Zhao, Y]]
[[Category: Zhao Y]]
[[Category: Cryo-em]]
[[Category: Dispatched]]
[[Category: Hedgehog release]]
[[Category: Hedgehog signaling]]
[[Category: Membrane protein]]
[[Category: Setrol sensing domain]]
[[Category: Water bear]]

Latest revision as of 05:10, 12 June 2024

Cryo-EM structure of the hedgehog release protein Disp from water bear (Hypsibius dujardini)

7fif, resolution 6.50Å

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