1hv2: Difference between revisions

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==SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE==

== Structural highlights ==

<table><tr><td colspan='2'>[[1hv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV2 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1HV2 FirstGlance].

<table><tr><td colspan='2'>[[1hv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV2 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1HV2 FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1hv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv2 OCA], [https://pdbe.org/1hv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hv2 RCSB], [https://www.ebi.ac.uk/pdbsum/1hv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hv2 ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1hv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv2 OCA], [https://pdbe.org/1hv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hv2 RCSB], [https://www.ebi.ac.uk/pdbsum/1hv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hv2 ProSAT]</td></tr>

</table>

== Function ==

[[https://www.uniprot.org/uniprot/ELOC_YEAST ELOC_YEAST]] Prevents degradation of interacting proteins like PCL6 by the proteasome.<ref>PMID:11864988</ref> [[https://www.uniprot.org/uniprot/VHL_MOUSE VHL_MOUSE]] Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).

[https://www.uniprot.org/uniprot/ELOC_YEAST ELOC_YEAST] Prevents degradation of interacting proteins like PCL6 by the proteasome.<ref>PMID:11864988</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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__TOC__

</StructureSection>

~~[[Category: Atcc 18824]]~~

[[Category: Large Structures]]

[[Category: ~~Arrowsmith, C H~~]]

[[Category: Mus musculus]]

[[Category: ~~Botuyan, M V~~]]

[[Category: Saccharomyces cerevisiae]]

[[Category: ~~Case, D A~~]]

[[Category: Arrowsmith CH]]

[[Category: ~~Chazin, W J~~]]

[[Category: Botuyan MV]]

[[Category: ~~Edwards, A M~~]]

[[Category: Case DA]]

[[Category: ~~Koth, C M~~]]

[[Category: Chazin WJ]]

[[Category: ~~Mer, G~~]]

[[Category: Edwards AM]]

[[Category: ~~Yi, G S~~]]

[[Category: Koth CM]]

[[Category: ~~Protein-peptide complex~~]]

[[Category: Mer G]]

[[Category: ~~Signaling protein~~]]

[[Category: Yi G-S]]

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@@ Line 1: / Line 1: @@
 ==SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE==
-<StructureSection load='1hv2' size='340' side='right'caption='[[1hv2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1hv2' size='340' side='right'caption='[[1hv2]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1hv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HV2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1hv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HV2 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv2 OCA], [https://pdbe.org/1hv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hv2 RCSB], [https://www.ebi.ac.uk/pdbsum/1hv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hv2 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv2 OCA], [https://pdbe.org/1hv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hv2 RCSB], [https://www.ebi.ac.uk/pdbsum/1hv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hv2 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/ELOC_YEAST ELOC_YEAST]] Prevents degradation of interacting proteins like PCL6 by the proteasome.<ref>PMID:11864988</ref>  [[https://www.uniprot.org/uniprot/VHL_MOUSE VHL_MOUSE]] Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).
+[https://www.uniprot.org/uniprot/ELOC_YEAST ELOC_YEAST] Prevents degradation of interacting proteins like PCL6 by the proteasome.<ref>PMID:11864988</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 34: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Atcc 18824]]
 [[Category: Large Structures]]
-[[Category: Arrowsmith, C H]]
+[[Category: Mus musculus]]
-[[Category: Botuyan, M V]]
+[[Category: Saccharomyces cerevisiae]]
-[[Category: Case, D A]]
+[[Category: Arrowsmith CH]]
-[[Category: Chazin, W J]]
+[[Category: Botuyan MV]]
-[[Category: Edwards, A M]]
+[[Category: Case DA]]
-[[Category: Koth, C M]]
+[[Category: Chazin WJ]]
-[[Category: Mer, G]]
+[[Category: Edwards AM]]
-[[Category: Yi, G S]]
+[[Category: Koth CM]]
-[[Category: Protein-peptide complex]]
+[[Category: Mer G]]
-[[Category: Signaling protein]]
+[[Category: Yi G-S]]