7qux: Difference between revisions
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==Crystal structure of P7C8 bound to CK2alpha== | |||
<StructureSection load='7qux' size='340' side='right'caption='[[7qux]], [[Resolution|resolution]] 1.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7qux]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OUT:CARBAMIC+ACID'>OUT</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qux OCA], [https://pdbe.org/7qux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qux RCSB], [https://www.ebi.ac.uk/pdbsum/7qux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qux ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
In this work, an iterative cycle of enzymatic assays, X-ray crystallography, molecular modelling and cellular assays were used to develop a functionalisable chemical probe for the CK2alpha/beta PPI. The lead peptide, P8C9, successfully binds to CK2alpha at the PPI site, is easily synthesisable and functionalisable, highly stable in serum and small enough to accommodate further optimisation. | |||
Development of small cyclic peptides targeting the CK2alpha/beta interface.,Atkinson EL, Iegre J, D'Amore C, Brear P, Salvi M, Hyvonen M, Spring DR Chem Commun (Camb). 2022 Apr 12;58(30):4791-4794. doi: 10.1039/d2cc00707j. PMID:35343996<ref>PMID:35343996</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 7qux" style="background-color:#fffaf0;"></div> | ||
[[Category: Baker | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Iegre | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Synthetic construct]] | |||
[[Category: Atkinson E]] | |||
[[Category: Baker D]] | |||
[[Category: Brear P]] | |||
[[Category: Hyvonen M]] | |||
[[Category: Iegre J]] | |||
[[Category: Sore H]] | |||
[[Category: Spring D]] | |||
Latest revision as of 09:07, 17 October 2024
Crystal structure of P7C8 bound to CK2alpha
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