7u2n: Difference between revisions

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'''Unreleased structure'''


The entry 7u2n is ON HOLD
==A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-open state==
 
<StructureSection load='7u2n' size='340' side='right'caption='[[7u2n]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7u2n]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U2N FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=L2L:aminomethanesulfonic+acid'>L2L</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u2n OCA], [https://pdbe.org/7u2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u2n RCSB], [https://www.ebi.ac.uk/pdbsum/7u2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u2n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLRA1_DANRE GLRA1_DANRE] Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:10188956, PubMed:26344198). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity).[UniProtKB:P23415]<ref>PMID:10188956</ref> <ref>PMID:26344198</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Gouaux E]]
[[Category: Zhu H]]
Retrieved from "https://proteopedia.org/7u2n"