7t5k: Difference between revisions
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==E. coli dihydroorotate dehydrogenase bound to the inhibitor HQNO== | ==E. coli dihydroorotate dehydrogenase bound to the inhibitor HQNO== | ||
<StructureSection load='7t5k' size='340' side='right'caption='[[7t5k]]' scene=''> | <StructureSection load='7t5k' size='340' side='right'caption='[[7t5k]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5K FirstGlance]. <br> | <table><tr><td colspan='2'>[[7t5k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5K FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5k OCA], [https://pdbe.org/7t5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5k RCSB], [https://www.ebi.ac.uk/pdbsum/7t5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5k ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=HQO:2-HEPTYL-4-HYDROXY+QUINOLINE+N-OXIDE'>HQO</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5k OCA], [https://pdbe.org/7t5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5k RCSB], [https://www.ebi.ac.uk/pdbsum/7t5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5k ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PYRD_ECOLI PYRD_ECOLI] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.<ref>PMID:10074342</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HAQs and open the door to downstream structure-activity relationship studies. | |||
Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines.,Horwitz SM, Blue TC, Ambarian JA, Hoshino S, Seyedsayamdost MR, Davis KM RSC Chem Biol. 2022 Feb 7;3(4):420-425. doi: 10.1039/d1cb00255d. eCollection 2022, Apr 6. PMID:35441142<ref>PMID:35441142</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7t5k" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ambarian JA]] | [[Category: Ambarian JA]] | ||
[[Category: Davis KM]] | [[Category: Davis KM]] | ||
[[Category: Horwitz SM]] | [[Category: Horwitz SM]] | ||
