7thk: Difference between revisions
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==Cryo-EM structure of prefusion SARS-CoV-2 spike omicron B.1.1.529 variant== | ==Cryo-EM structure of prefusion SARS-CoV-2 spike omicron B.1.1.529 variant== | ||
<StructureSection load='7thk' size='340' side='right'caption='[[7thk]]' scene=''> | <StructureSection load='7thk' size='340' side='right'caption='[[7thk]], [[Resolution|resolution]] 3.11Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7THK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7THK FirstGlance]. <br> | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7THK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7THK FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7thk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7thk OCA], [https://pdbe.org/7thk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7thk RCSB], [https://www.ebi.ac.uk/pdbsum/7thk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7thk ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.11Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7thk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7thk OCA], [https://pdbe.org/7thk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7thk RCSB], [https://www.ebi.ac.uk/pdbsum/7thk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7thk ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The recently reported B.1.1.529 Omicron variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) includes 34 mutations in the spike protein relative to the Wuhan strain, including 15 mutations in the receptor-binding domain (RBD). Functional studies have shown Omicron to substantially escape the activity of many SARS-CoV-2-neutralizing antibodies. Here, we report a 3.1 A-resolution cryoelectron microscopy (cryo-EM) structure of the Omicron spike protein ectodomain. The structure depicts a spike that is exclusively in the 1-RBD-up conformation with high mobility of RBD. Many mutations cause steric clashes and/or altered interactions at antibody-binding surfaces, whereas others mediate changes of the spike structure in local regions to interfere with antibody recognition. Overall, the structure of the Omicron spike reveals how mutations alter its conformation and explains its extraordinary ability to evade neutralizing antibodies. | |||
Cryo-EM structure of the SARS-CoV-2 Omicron spike.,Cerutti G, Guo Y, Liu L, Liu L, Zhang Z, Luo Y, Huang Y, Wang HH, Ho DD, Sheng Z, Shapiro L Cell Rep. 2022 Feb 7:110428. doi: 10.1016/j.celrep.2022.110428. PMID:35172173<ref>PMID:35172173</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7thk" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Latest revision as of 14:03, 6 November 2024
Cryo-EM structure of prefusion SARS-CoV-2 spike omicron B.1.1.529 variant
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