1tey: Difference between revisions
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==NMR structure of human histone chaperone, ASF1A== | ==NMR structure of human histone chaperone, ASF1A== | ||
<StructureSection load='1tey' size='340' side='right'caption='[[1tey | <StructureSection load='1tey' size='340' side='right'caption='[[1tey]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tey]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1tey]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TEY FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tey OCA], [https://pdbe.org/1tey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tey RCSB], [https://www.ebi.ac.uk/pdbsum/1tey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tey ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tey OCA], [https://pdbe.org/1tey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tey RCSB], [https://www.ebi.ac.uk/pdbsum/1tey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tey ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ASF1A_HUMAN ASF1A_HUMAN] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.<ref>PMID:10759893</ref> <ref>PMID:11897662</ref> <ref>PMID:12842904</ref> <ref>PMID:14718166</ref> <ref>PMID:15621527</ref> <ref>PMID:16151251</ref> <ref>PMID:15664198</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Agez | [[Category: Agez M]] | ||
[[Category: Amigues | [[Category: Amigues B]] | ||
[[Category: Courbeyrette | [[Category: Courbeyrette R]] | ||
[[Category: Guerois | [[Category: Guerois R]] | ||
[[Category: Lautrette | [[Category: Lautrette A]] | ||
[[Category: Mann | [[Category: Mann C]] | ||
[[Category: Mousson | [[Category: Mousson F]] | ||
[[Category: Neumann | [[Category: Neumann JM]] | ||
[[Category: Ochsenbein | [[Category: Ochsenbein F]] | ||
[[Category: Thuret | [[Category: Thuret JY]] | ||
Latest revision as of 09:12, 22 May 2024
NMR structure of human histone chaperone, ASF1A
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