RmlC

spinqualitylabelsall models Structure of RmlC complex with dTPD-rhamnose (PDB code 2ixc). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function RmlC or dTDP-4-dehydrorhamnose 3,5-epimerase or dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase is an epimerase enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human. Relevance Inhibitors of RmlC can serve as potential antimicrobial drugs. Structural highlights The active site of RmlC contains the reaction product DTDP-L-rhamnose. Water molecules are shown as red spheres.

3D structures of RmlC

Updated on 06-March-2022

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• RmlC
  • 1pm7, 1upi – MtRmlC – Mycobacterium tuberculosis
    
  • 2ixj, 1rtv – PaRmlC – Pseudomonas aeruginosa
    
  • 1nxm – SsRmlC – Streptococcus suis
    
  • 1ep0 – MetRmlC – Methanothermobacter thermautotrophicus
    
  • 1dzr – StRmlC – Salmonella typhimurium
    
• RmlC complexes
  • 2ixc – MtRmlC + dTDP rhamnose
    
  • 2ixh – PaRmlC + dTDP rhamnose
    
  • 2ixl – SsRmlC + dTDP rhamnose
    
  • 2ixk – PaRmlC + dTDP-keto rhamnose
    
  • 6ndr – RmlC + dTDP-keto rhamnose – Legionella pneumophila
    
  • 1nyw – SsRmlC + dTDP glucose
    
  • 1nzc – SsRmlC + dTDP xylose
    
  • 1epz – MetRmlC + TDP
    
  • 3ryk – RmlC + TDP + pyrophosphate – Bacillus anthracis
    
  • 1dzt – StRmlC + acetylthymidine diphosphate
    

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