7x6w: Difference between revisions
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==SFTSV 2 fold hexamer== | |||
<StructureSection load='7x6w' size='340' side='right'caption='[[7x6w]], [[Resolution|resolution]] 5.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7x6w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_fever_with_thrombocytopenia_syndrome_virus Severe fever with thrombocytopenia syndrome virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X6W FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.18Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x6w OCA], [https://pdbe.org/7x6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x6w RCSB], [https://www.ebi.ac.uk/pdbsum/7x6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x6w ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GP_SFTSV GP_SFTSV] Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after clathrin-mediated endocytosis of the virion (By similarity). Plays a role in the packaging of ribonucleoproteins and polymerase during virus assembly (PubMed:29467349).[UniProtKB:P09613][UniProtKB:P21401][UniProtKB:R4V2Q5]<ref>PMID:29467349</ref> Structural component of the virion that interacts with glycoprotein N (By similarity). Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after clathrin-mediated endocytosis of the virion (By similarity).[UniProtKB:P09613][UniProtKB:P21401][UniProtKB:R4V2Q5] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Severe fever with thrombocytopenia syndrome virus]] | |||
[[Category: Lou Z]] | |||
[[Category: Sun Z]] | |||
