7x84: Difference between revisions
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New page: '''Unreleased structure''' The entry 7x84 is ON HOLD Authors: Zhao, Q.Y., Xia, W.C., Fan, Y., Sun, Y.P., Tao, Y.Q., Liu, C. Description: Cryo-EM structure of the TMEM106B fibril from P... |
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==Cryo-EM structure of the TMEM106B fibril from Parkinson's disease dementia== | |||
<StructureSection load='7x84' size='340' side='right'caption='[[7x84]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7x84]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X84 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x84 OCA], [https://pdbe.org/7x84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x84 RCSB], [https://www.ebi.ac.uk/pdbsum/7x84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x84 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: Liu | [https://www.uniprot.org/uniprot/T106B_HUMAN T106B_HUMAN] Progressive non-fluent aphasia;Semantic dementia;Behavioral variant of frontotemporal dementia. The gene represented in this entry acts as a disease modifier. Risk alleles confer genetic susceptibility by increasing gene expression (PubMed:20154673, PubMed:21178100). Increased expression may be the result of down-regulation of microRNA miR-132 and miR-212, that repress TMEM106B expression (PubMed:22895706). Thr-185 is a risk allele associated with lower GRN protein levels and early age at onset in GRN UP-FTD mutation carriers: it presents slower protein degradation that leads to higher steady-state TMEM106B levels, leading to alterations in the intracellular versus extracellular partitioning of GRN (PubMed:23742080).<ref>PMID:20154673</ref> <ref>PMID:21178100</ref> <ref>PMID:22895706</ref> <ref>PMID:23742080</ref> The gene represented in this entry acts as a disease modifier. The disease may be caused by variants affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/T106B_HUMAN T106B_HUMAN] Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.<ref>PMID:23136129</ref> <ref>PMID:24357581</ref> | ||
[[Category: Zhao | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Fan Y]] | |||
[[Category: Liu C]] | |||
[[Category: Sun YP]] | |||
[[Category: Tao YQ]] | |||
[[Category: Xia WC]] | |||
[[Category: Zhao QY]] | |||
Latest revision as of 14:12, 6 November 2024
Cryo-EM structure of the TMEM106B fibril from Parkinson's disease dementia
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