3h4l: Difference between revisions

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<StructureSection load='3h4l' size='340' side='right'caption='[[3h4l]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3h4l' size='340' side='right'caption='[[3h4l]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3h4l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H4L FirstGlance]. <br>
<table><tr><td colspan='2'>[[3h4l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H4L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PMS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h4l OCA], [https://pdbe.org/3h4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h4l RCSB], [https://www.ebi.ac.uk/pdbsum/3h4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h4l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h4l OCA], [https://pdbe.org/3h4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h4l RCSB], [https://www.ebi.ac.uk/pdbsum/3h4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h4l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PMS1_YEAST PMS1_YEAST]] Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates.<ref>PMID:9545323</ref> <ref>PMID:10570173</ref> <ref>PMID:16227575</ref>
[https://www.uniprot.org/uniprot/PMS1_YEAST PMS1_YEAST] Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates.<ref>PMID:9545323</ref> <ref>PMID:10570173</ref> <ref>PMID:16227575</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 3h4l" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3h4l" style="background-color:#fffaf0;"></div>
==See Also==
*[[DNA mismatch repair protein 3D structures|DNA mismatch repair protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arana, M E]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Fortune, J M]]
[[Category: Arana ME]]
[[Category: Holmes, S F]]
[[Category: Fortune JM]]
[[Category: Kunkel, T A]]
[[Category: Holmes SF]]
[[Category: Moon, A F]]
[[Category: Kunkel TA]]
[[Category: Pedersen, L C]]
[[Category: Moon AF]]
[[Category: Atp binding]]
[[Category: Pedersen LC]]
[[Category: Dna binding protein]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Pms1]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/3h4l"