7u8u: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 7u8u is ON HOLD  until Paper Publication
==hTRAP1 with inhibitors==
 
<StructureSection load='7u8u' size='340' side='right'caption='[[7u8u]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
Authors: Deng, J., Matts, R., Peng, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7u8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U8U FirstGlance]. <br>
Description: hTRAP1 with inhibitors
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.065&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UJY:[2-hydroxy-5-(2H-isoindole-2-carbonyl)phenyl]{5-[3-(triphenyl-lambda~5~-phosphanyl)propoxy]-2H-isoindol-2-yl}methanone'>UJY</scene></td></tr>
[[Category: Matts, R]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u8u OCA], [https://pdbe.org/7u8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u8u RCSB], [https://www.ebi.ac.uk/pdbsum/7u8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u8u ProSAT]</span></td></tr>
[[Category: Deng, J]]
</table>
[[Category: Peng, S]]
== Function ==
[https://www.uniprot.org/uniprot/TRAP1_HUMAN TRAP1_HUMAN] Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.<ref>PMID:23525905</ref> <ref>PMID:23564345</ref> <ref>PMID:23747254</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Deng J]]
[[Category: Matts R]]
[[Category: Peng S]]
Retrieved from "https://proteopedia.org/7u8u"