7x5e: Difference between revisions

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'''Unreleased structure'''


The entry 7x5e is ON HOLD  until Paper Publication
==Nrf2-MafG heterodimer bound with CsMBE1==
 
<StructureSection load='7x5e' size='340' side='right'caption='[[7x5e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7x5e]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X5E FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x5e OCA], [https://pdbe.org/7x5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x5e RCSB], [https://www.ebi.ac.uk/pdbsum/7x5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x5e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAFG_HUMAN MAFG_HUMAN] Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity).[UniProtKB:Q76MX4]<ref>PMID:11154691</ref> <ref>PMID:8932385</ref> <ref>PMID:9421508</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Baba S]]
[[Category: Hamada K]]
[[Category: Motohashi H]]
[[Category: Ogata K]]
[[Category: Ohta T]]
[[Category: Okada C]]
[[Category: Sato K]]
[[Category: Sengoku T]]
[[Category: Shiina M]]
[[Category: Suzuki K]]
[[Category: Uchiyama A]]
[[Category: Yamamoto M]]
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