7yzb: Difference between revisions
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==Crystal structure of the human FoxH1 bound to the TGTGGATT site== | |||
<StructureSection load='7yzb' size='340' side='right'caption='[[7yzb]], [[Resolution|resolution]] 1.47Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7yzb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YZB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yzb OCA], [https://pdbe.org/7yzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yzb RCSB], [https://www.ebi.ac.uk/pdbsum/7yzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yzb ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/FOXH1_HUMAN FOXH1_HUMAN] Septopreoptic holoprosencephaly;Semilobar holoprosencephaly;Lobar holoprosencephaly;Alobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly;Microform holoprosencephaly. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FOXH1_HUMAN FOXH1_HUMAN] Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).<ref>PMID:9702198</ref> | |||
==See Also== | |||
*[[FOX 3D structures|FOX 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Macias MJ]] | |||
[[Category: Pluta R]] | |||
Latest revision as of 13:27, 1 February 2024
Crystal structure of the human FoxH1 bound to the TGTGGATT site
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