5hyg: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
Line 3: Line 3:
<StructureSection load='5hyg' size='340' side='right'caption='[[5hyg]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
<StructureSection load='5hyg' size='340' side='right'caption='[[5hyg]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5hyg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strvp Strvp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HYG FirstGlance]. <br>
<table><tr><td colspan='2'>[[5hyg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae_ATCC_10712 Streptomyces venezuelae ATCC 10712]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HYG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5hyh|5hyh]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SVEN_0924 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=953739 STRVP])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyg OCA], [https://pdbe.org/5hyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hyg RCSB], [https://www.ebi.ac.uk/pdbsum/5hyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyg OCA], [https://pdbe.org/5hyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hyg RCSB], [https://www.ebi.ac.uk/pdbsum/5hyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CMLI_STRVP CMLI_STRVP] Involved in chloramphenicol biosynthesis (PubMed:24347692, PubMed:25564306). Catalyzes the six-electron oxidation of an aryl-amine precursor of chloramphenicol (NH2-CAM) to yield the aryl-nitro group of chloramphenicol (CAM) (PubMed:24347692, PubMed:25564306, PubMed:27203126). During catalysis, upon exposure of the diferrous cluster to O(2), ClmI forms an exceptionally long-lived peroxo intermediate (CmlI-peroxo), which reacts with NH2-CAM to form CAM (PubMed:25564306, PubMed:27203126).<ref>PMID:24347692</ref> <ref>PMID:25564306</ref> <ref>PMID:27203126</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 24:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Strvp]]
[[Category: Streptomyces venezuelae ATCC 10712]]
[[Category: Knoot, C J]]
[[Category: Knoot CJ]]
[[Category: Lipscomb, J D]]
[[Category: Lipscomb JD]]
[[Category: Antibiotic biosynthesis]]
[[Category: Diiron cluster]]
[[Category: Metal binding protein]]
[[Category: Non-heme iron]]
[[Category: Oxygen activation]]
Retrieved from "https://proteopedia.org/5hyg"