7u19: Difference between revisions

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'''Unreleased structure'''


The entry 7u19 is ON HOLD  until Paper Publication
==RFC:PCNA bound to nicked DNA==
<StructureSection load='7u19' size='340' side='right'caption='[[7u19]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7u19]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U19 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u19 OCA], [https://pdbe.org/7u19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u19 RCSB], [https://www.ebi.ac.uk/pdbsum/7u19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u19 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RFC1_YEAST RFC1_YEAST] Component of the ATP-dependent clamp loader RFC complex for the POL30/PCNA homotrimer DNA clamp. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Replication factor C (RFC or activator 1) complex acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment.


Authors: Liu, X., Gaubitz, C., Pajak, J., Kelch, B.A.
==See Also==
 
*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]]
Description: RFC:PCNA bound to nicked DNA
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Gaubitz, C]]
[[Category: Large Structures]]
[[Category: Liu, X]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Kelch, B.A]]
[[Category: Synthetic construct]]
[[Category: Pajak, J]]
[[Category: Gaubitz C]]
[[Category: Kelch BA]]
[[Category: Liu X]]
[[Category: Pajak J]]
Retrieved from "https://proteopedia.org/7u19"