7x5o: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 7x5o is ~~ON HOLD until Paper Publication~~

==Crystal structure of E. faecium SHMT in complex with Me-THF and PLP-Gly==

== Structural highlights ==

<table><tr><td colspan='2'>[[7x5o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X5O OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7X5O FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene>, <scene name='pdbligand=THH:N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC+ACID'>THH</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7x5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x5o OCA], [https://pdbe.org/7x5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x5o RCSB], [https://www.ebi.ac.uk/pdbsum/7x5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x5o ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/A0A133CK16_ENTFC A0A133CK16_ENTFC] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]

~~Authors~~:

==See Also==

*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]

~~Description~~:

__TOC__

[[Category: ~~Unreleased Structures~~]]

</StructureSection>

[[Category: Enterococcus faecium]]

[[Category: Large Structures]]

[[Category: Hasegawa K]]

[[Category: Hayashi H]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7x5o is ON HOLD  until Paper Publication
+==Crystal structure of E. faecium SHMT in complex with Me-THF and PLP-Gly==
+<StructureSection load='7x5o' size='340' side='right'caption='[[7x5o]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7x5o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X5O FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene>, <scene name='pdbligand=THH:N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC+ACID'>THH</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x5o OCA], [https://pdbe.org/7x5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x5o RCSB], [https://www.ebi.ac.uk/pdbsum/7x5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x5o ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A133CK16_ENTFC A0A133CK16_ENTFC] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
-Authors:
+==See Also==
+*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
-Description:
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
+[[Category: Enterococcus faecium]]
+[[Category: Large Structures]]
+[[Category: Hasegawa K]]
+[[Category: Hayashi H]]