7z9l: Difference between revisions

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'''Unreleased structure'''


The entry 7z9l is ON HOLD  until Paper Publication
==Phen-DC3 intercalation causes hybrid-to-antiparallel transformation of human telomeric DNA G-quadruplex==
<StructureSection load='7z9l' size='340' side='right'caption='[[7z9l]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7z9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z9L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PQ3:N2,N9-BIS(1-METHYLQUINOLIN-3-YL)-1,10-PHENANTHROLINE-2,9-DICARBOXAMIDE'>PQ3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z9l OCA], [https://pdbe.org/7z9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z9l RCSB], [https://www.ebi.ac.uk/pdbsum/7z9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z9l ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human telomeric G-quadruplex DNA structures are attractive anticancer drug targets, but the target's polymorphism complicates the drug design: different ligands prefer different folds, and very few complexes have been solved at high resolution. Here we report that Phen-DC3 , one of the most prominent G-quadruplex ligands in terms of high binding affinity and selectivity, causes dTAGGG(TTAGGG)3 to completely change its fold in KCl solution from a hybrid-1 to an antiparallel chair-type structure, wherein the ligand intercalates between a two-quartet unit and a pseudo-quartet, thereby ejecting one potassium ion. This unprecedented high-resolution NMR structure shows for the first time a true ligand intercalation into an intramolecular G-quadruplex.


Authors:  
Phen-DC3 Induces Refolding of Human Telomeric DNA into a Chair-Type Antiparallel G-Quadruplex through Ligand Intercalation.,Ghosh A, Trajkovski M, Teulade-Fichou MP, Gabelica V, Plavec J Angew Chem Int Ed Engl. 2022 Aug 22:e202207384. doi: 10.1002/anie.202207384. PMID:35993443<ref>PMID:35993443</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 7z9l" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gabelica V]]
[[Category: Ghosh A]]
[[Category: Plavec J]]
[[Category: Teulade-Fichou MP]]
[[Category: Trajkovski M]]
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