7zej: Difference between revisions

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'''Unreleased structure'''


The entry 7zej is ON HOLD
==Crystal structure of the human MGC45594 gene product in complex with celecoxib.==
 
<StructureSection load='7zej' size='340' side='right'caption='[[7zej]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
Authors: Shafqat, N., Yue, W.W., Koekemoer, L., Niesen, F., Ugochukwu, E., Vollmar, M., Weigelt, J., Krojer, T., Pike, A., Chaikaud, A., Von Delft, F., Arrowsmith, C., Bountra, C., Edwards, A., Opperman, U.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7zej]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEJ FirstGlance]. <br>
Description: Crystal structure of the human MGC45594 gene product in complex with celecoxib.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEL:4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE'>CEL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
[[Category: Chaikaud, A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zej OCA], [https://pdbe.org/7zej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zej RCSB], [https://www.ebi.ac.uk/pdbsum/7zej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zej ProSAT]</span></td></tr>
[[Category: Niesen, F]]
</table>
[[Category: Yue, W.W]]
== Function ==
[[Category: Von Delft, F]]
[https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4]
[[Category: Koekemoer, L]]
__TOC__
[[Category: Arrowsmith, C]]
</StructureSection>
[[Category: Pike, A]]
[[Category: Homo sapiens]]
[[Category: Shafqat, N]]
[[Category: Large Structures]]
[[Category: Edwards, A]]
[[Category: Arrowsmith C]]
[[Category: Krojer, T]]
[[Category: Bountra C]]
[[Category: Opperman, U]]
[[Category: Chaikaud A]]
[[Category: Weigelt, J]]
[[Category: Edwards A]]
[[Category: Ugochukwu, E]]
[[Category: Koekemoer L]]
[[Category: Bountra, C]]
[[Category: Krojer T]]
[[Category: Vollmar, M]]
[[Category: Niesen F]]
[[Category: Opperman U]]
[[Category: Pike A]]
[[Category: Shafqat N]]
[[Category: Ugochukwu E]]
[[Category: Vollmar M]]
[[Category: Von Delft F]]
[[Category: Weigelt J]]
[[Category: Yue WW]]

Latest revision as of 13:31, 1 February 2024

Crystal structure of the human MGC45594 gene product in complex with celecoxib.

7zej, resolution 1.79Å

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