3i53: Difference between revisions

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<StructureSection load='3i53' size='340' side='right'caption='[[3i53]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
<StructureSection load='3i53' size='340' side='right'caption='[[3i53]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3i53]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"streptomyces_carzinostaticus_subsp._neocarzinostaticus"_ishida_et_al. "streptomyces carzinostaticus subsp. neocarzinostaticus" ishida et al.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I53 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3i53]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_carzinostaticus_subsp._neocarzinostaticus Streptomyces carzinostaticus subsp. neocarzinostaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I53 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3i58|3i58]], [[3i5u|3i5u]], [[3i64|3i64]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ncsb1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=167636 "Streptomyces carzinostaticus subsp. neocarzinostaticus" Ishida et al.])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i53 OCA], [https://pdbe.org/3i53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i53 RCSB], [https://www.ebi.ac.uk/pdbsum/3i53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i53 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i53 OCA], [https://pdbe.org/3i53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i53 RCSB], [https://www.ebi.ac.uk/pdbsum/3i53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i53 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NCSB1_STRCZ NCSB1_STRCZ]] S-adenosyl-L-methionine-dependent O-methyltransferase that catalyzes regiospecific methylation at the 7-hydroxy group of 2,7-dihydroxy-5-methyl-1-naphthoate in the biosynthesis of the naphthoate moiety of the neocarzinostatin chromophore. Also recognizes other dihydroxynaphthoate as substrates and catalyzes their regiospecific O-methylation. The carboxylate and its ortho-hydroxy groups of the substrate appear to be crucial for NcsB1 substrate recognition and binding, and O-methylation takes place only at the free hydroxy group of these dihydroxynaphthoic acids.<ref>PMID:18387946</ref>
[https://www.uniprot.org/uniprot/NCSB1_STRCZ NCSB1_STRCZ] S-adenosyl-L-methionine-dependent O-methyltransferase that catalyzes regiospecific methylation at the 7-hydroxy group of 2,7-dihydroxy-5-methyl-1-naphthoate in the biosynthesis of the naphthoate moiety of the neocarzinostatin chromophore. Also recognizes other dihydroxynaphthoate as substrates and catalyzes their regiospecific O-methylation. The carboxylate and its ortho-hydroxy groups of the substrate appear to be crucial for NcsB1 substrate recognition and binding, and O-methylation takes place only at the free hydroxy group of these dihydroxynaphthoic acids.<ref>PMID:18387946</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptomyces carzinostaticus subsp. neocarzinostaticus ishida et al]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bruner, S D]]
[[Category: Streptomyces carzinostaticus subsp. neocarzinostaticus]]
[[Category: Cooke, H A]]
[[Category: Bruner SD]]
[[Category: Co-complex]]
[[Category: Cooke HA]]
[[Category: Methyltransferase]]
[[Category: Rossmann-like fold]]
[[Category: Transferase]]
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