7xi4: Difference between revisions
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==Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA== | |||
<StructureSection load='7xi4' size='340' side='right'caption='[[7xi4]], [[Resolution|resolution]] 4.71Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7xi4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XI4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.707Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xi4 OCA], [https://pdbe.org/7xi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xi4 RCSB], [https://www.ebi.ac.uk/pdbsum/7xi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xi4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). | |||
==See Also== | |||
*[[3D structures of hypoxia-inducible factor|3D structures of hypoxia-inducible factor]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: | [[Category: Jing LQ]] | ||
[[Category: | [[Category: Li FW]] | ||
[[Category: Sun XN]] | |||
[[Category: Wu DL]] | |||
Latest revision as of 17:54, 29 November 2023
Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA
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