7zan: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 7zan is ON HOLD  until sometime in the future
==Crystal Structure of human IL-17A in complex with IL-17RA and IL-17RC==
<StructureSection load='7zan' size='340' side='right'caption='[[7zan]], [[Resolution|resolution]] 5.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zan]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZAN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.061&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zan OCA], [https://pdbe.org/7zan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zan RCSB], [https://www.ebi.ac.uk/pdbsum/7zan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zan ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Signaling through innate immune receptors such as the Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) superfamily proceeds via the assembly of large membrane-proximal complexes or "signalosomes." Although structurally distinct, the IL-17 receptor family triggers cellular responses that are typical of innate immune receptors. The IL-17RA receptor subunit is shared by several members of the IL-17 family. Using a combination of crystallographic, biophysical, and mutational studies, we show that IL-17A, IL-17F, and IL-17A/F induce IL-17RA dimerization. X-ray analysis of the heteromeric IL-17A complex with the extracellular domains of the IL-17RA and IL-17RC receptors reveals that cytokine-induced IL-17RA dimerization leads to the formation of a 2:2:2 hexameric signaling assembly. Furthermore, we demonstrate that the formation of the IL-17 signalosome potentiates IL-17-induced IL-36gamma and CXCL1 mRNA expression in human keratinocytes, compared with a dimerization-defective IL-17RA variant.


Authors: Rondeau, J.M., Goepfert, A.
IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.,Goepfert A, Barske C, Lehmann S, Wirth E, Willemsen J, Gudjonsson JE, Ward NL, Sarkar MK, Hemmig R, Kolbinger F, Rondeau JM Cell Rep. 2022 Oct 18;41(3):111489. doi: 10.1016/j.celrep.2022.111489. PMID:36260993<ref>PMID:36260993</ref>


Description: Crystal Structure of human IL-17A in complex with IL-17RA and IL-17RC
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Rondeau, J.M]]
<div class="pdbe-citations 7zan" style="background-color:#fffaf0;"></div>
[[Category: Goepfert, A]]
 
==See Also==
*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Goepfert A]]
[[Category: Rondeau JM]]
Retrieved from "https://proteopedia.org/7zan"